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Example sentences for: dbdgd

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The high-scoring segment pairs (HSPs) detected in these searches aligned the highly conserved region of the RDRPs between the predicted strands 18 and 20, including the DbDGD motif, with the portion of the DDRP β' subunit sequence, which contains the metal-chelating active site, with a similar conserved motif, DxDGD.
Taken together, these observations suggest that, although RDRPs and the β' subunits of DDRPs show limited sequence similarity, these two RNA polymerase families share a homologous catalytic domain, which consists of a double-psi-β-barrel containing the metal-coordinating DbDGD motif.
Closely spaced acidic residues that coordinate divalent cations are characteristic of the active sites of most nucleic acid polymerases, in spite of the fact that they belong to several unrelated structural folds [ 9 13 14 17 28 29 59 ] . Given that the DbDGD motif is the only set of closely spaced acidic residues shared by the RDRPs and the YRHs, it is likely to form part of the nucleotidyltransferase active site of these enzymes.
This domain adopts the DPBB fold, in which the signature DbDGD motif, shared by RDRP and DDRP, is ensconced in the insert between the ultimate and penultimate β-strands.
One of these blocks centered at the DbDGD motif, whereas the other one encompassed strands 3 and 4, which contain several partially conserved hydrophobic and polar positions (Fig.