Words similar to dbf
Example sentences for: dbf
How can you use “dbf” in a sentence? Here are some example sentences to help you improve your vocabulary:
Cdc5 presumably impinges on the MEN by other means as well, because Cdc5 is required for maximal Dbf2 protein kinase activity even in the absence of Bfa1's obligate partner Bub2 [ 18 ] . Once activated, the MEN in turn sustains the transient Cdc14 release enabled by Cdc5 and other FEAR pathway components.
First, the sole essential function of the Tem1, Cdc15, Dbf2/Dbf20, and Mob1 (but not Cdc5) proteins are to promote the release of Cdc14 from the nucleolus, as cells lacking these proteins can grow upon simultaneous reduction of NET1 activity.
Cdc5 is required for full activation of the Dbf2-Mob1 protein kinase complex [ 15 16 17 ] , and has been proposed to impinge on the MEN both upstream and downstream of Tem1 [ 15 16 17 18 ] . During exit from mitosis, Cdc5 is required for Clb2 destruction, and similar to over-expression of Cdc14 [ 3 ] , induction of Cdc5 triggers precocious Clb2 degradation in pre-anaphase cells [ 19 20 ] . In addition to its role in exit from mitosis, Cdc5 has other functions during mitosis in budding yeast.
Cdc15, Dbf2, and Mob1 are not properly localized to the spindle pole body in a significant fraction of cdc5-1 cells [ 30 31 17 ] , and Dbf2/Mob1 protein kinase activity is diminished in cdc5 cells [ 15 16 17 ] , suggesting that at least one function of Cdc5 is to generate maximally active Dbf2/Mob1, which can then trigger Cdc14 release.
Li, personal communication), Cdc15 [ 28 ] , or Dbf2/GST-Mob1 (RA, unpublished data) had little or no detectable effect on either exit from mitosis or cell proliferation, suggesting that the Tem1/Cdc15/Dbf2/Mob1 branch of the MEN plays a more restricted role in promoting the exit from mitosis.
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