Example sentences for: dbp

How can you use “dbp” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • From each animal, quantitative real-time PCR determinations of 5 target genes ( cry1,2, per1,2 , and dbp ) and a reference cDNA (glyceraldehyde-3-phosphate dehydrogenase, g3pdh ) were made from the cortex, basal forebrain, and hypothalamus (primer/probe sequences available upon request).

  • Interestingly, in the latter study rNoc was identified among a group of clock-regulated genes that included Per1 , Per2 , Per3 , Bmal1 , and D-binding protein ( DBP ). Independent clock driven pathways may be critical in the function of many tissues and organs as suggested by the widespread expression of clock genes in peripheral tissues [ 7, 8, 10, 11, 12].

  • Deletion of the cryptochromes disinhibits the transcriptional activation of CLOCK:BMAL1 and NPAS2:BMAL1 target genes, resulting in increased levels of their transcripts in the SCN, liver, and retina [ 20 23 25 ] . We assayed the expression in the brain of three genes that are known targets of cryptochrome mediated transcriptional inhibition: albumin D-binding protein ( dbp [ 26 ] ), period (per)1 , and per2 [ 20 23 27 ] , in the middle of the daily light period.

  • The high per levels in cry1,2 -/-mice and the low per levels in clock mutant mice [ 26 47 ] correlate with their contrasting sleep phenotype (see above; [ 34 ] ). In this context, the sleep abnormalities in dbp -/-mice might also be related to a reduction in per expression since, at least in vitro , DBP can amplify the CLOCK:BMAL1-induced transcription of per [ 48 ] , but it is not known whether per transcript levels are altered in dbp -/-mice.

  • BP = blood pressure; HCTZ = hydrochlorothiazide; DBP = diastolic blood pressure; ITT = intent to treat; MCAR = missing completely at random; ICH = International Conference on Harmonization; LOCF last-observation-carried-forward; PMI = proper multiple imputation; MAR = missing at random; PI = partial imputation.

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