Words similar to dbp
Example sentences for: dbp
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These include: Spot14 (Thrsp), transcription factor 7 T-cell specific (Tcf7), transcription factor 2 (Tcf2), nuclear transcription factor-Y β(NF-Y β; Nfyb transcript), D site albumin promoter binding protein (Dbp), general transcription factor II (Gtf2I), activating transcription factor 5 (Atf5), Msx-interacting-zinc finger (Miz1), and pre B-cell leukemia transcription factor 1 (Pbx1).
The high per levels in cry1,2 -/-mice and the low per levels in clock mutant mice [ 26 47 ] correlate with their contrasting sleep phenotype (see above; [ 34 ] ). In this context, the sleep abnormalities in dbp -/-mice might also be related to a reduction in per expression since, at least in vitro , DBP can amplify the CLOCK:BMAL1-induced transcription of per [ 48 ] , but it is not known whether per transcript levels are altered in dbp -/-mice.
Albumin D-binding protein ( Dbp ) is a transcription factor whose expression is under the direct transcriptional control of CLOCK:BMAL1 [ 26 ] . Deletion of the dbp gene, which results in a shortening of the circadian period [ 35 ] , also results in decreased sleep consolidation and NREMS delta power [ 36 ] .
From each animal, quantitative real-time PCR determinations of 5 target genes ( cry1,2, per1,2 , and dbp ) and a reference cDNA (glyceraldehyde-3-phosphate dehydrogenase, g3pdh ) were made from the cortex, basal forebrain, and hypothalamus (primer/probe sequences available upon request).
Interestingly, in the latter study rNoc was identified among a group of clock-regulated genes that included Per1 , Per2 , Per3 , Bmal1 , and D-binding protein ( DBP ). Independent clock driven pathways may be critical in the function of many tissues and organs as suggested by the widespread expression of clock genes in peripheral tissues [ 7, 8, 10, 11, 12].
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