Words similar to caspases

Example sentences for: caspases

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While there is extensive crosstalk between the caspases, the two most common initiator pathways are the Fas/Fas ligand pathway, involving caspase 8 and caspase 10, and the mitochondrial pathway, triggering caspase 9 [ 24 25 ] . Caspase 3, a pivotal downstream protease, functions in virtually every caspase pathway and serves as an executioner in the cells by cleavage of downstream targets which lead to irreversible chromosomal degradation.
Bcl-2 impedes the subcellular trafficking of p53, inhibits downstream adapters necessary for stimulation of the apoptotic caspases, and can act as an antioxidant [ 15 28 ] .
Both cell lines produced activated caspases 8 and 9 by 1 h after treatment with equivalent levels at 3 h.
The essential step in plasma membrane destabilization and MP-release very likely is a caspase-dependent sphingomyelin hydrolysis, which leads to the production of ceramide [ 28 29 30 ] . It is possible, however, that sphingomyelin hydrolysis and MP-release may be a consequence of the action of initiator caspases or other ZVAD sensitive proteases rather than only executioner caspases [ 15 31 32 ] . Our study was performed in HUVEC culture, which may have particular properties in respect of MP release when compared with endothelial cells from other organs.
4), indicating that cleavage of Golgi autoantigens during apoptosis is mediated by caspases.