Words similar to caspases
Example sentences for: caspases
How can you use “caspases” in a sentence? Here are some example sentences to help you improve your vocabulary:
First, to determine whether a mutation in amino-terminal RING domain of BRCA1 preferentially targeted either the mitochondrial [ 25 ] or Fas/Fas ligand apoptotic pathway [ 24 ] , levels of the respective initiator caspases 9 and 8 were determined.
Lane et al . reported recently that the Golgi complex in HeLa cells is fragmented into scattered vesicles by caspases due to interference of Golgi reassembly and abnormalities of the 65 kDa stacking protein GRASP65 [ 32 ] . In the present report, we describe characteristic changes of the Golgi complex during the progression of apoptosis.
Under these conditions apoptosis may result from the production of cytokines [ 1 ] , cell activation [ 2 3 4 ] , infective agents [ 5 ] and adverse responses to pharmaceuticals [ 6 7 ] . Depending on the agonist or eliciting milieu, apoptotic cell death is accompanied by the activation of various cell death pathways including caspases, ceramide, altered gene expression, mitochondrial dysfunction and consumption of ATP e.g., with DNA repair, that result in histone-associated DNA fragmentation [ 8 9 ] . Many of these cell death pathways are also associated with the secondary production of oxidants [ 10 ] which appears to contribute to the magnitude of cell death.
While there is extensive crosstalk between the caspases, the two most common initiator pathways are the Fas/Fas ligand pathway, involving caspase 8 and caspase 10, and the mitochondrial pathway, triggering caspase 9 [ 24 25 ] . Caspase 3, a pivotal downstream protease, functions in virtually every caspase pathway and serves as an executioner in the cells by cleavage of downstream targets which lead to irreversible chromosomal degradation.
However, lipid hydroperoxide-induced apoptosis is accompanied by an alteration in the intracellular redox balance leading to a depletion of intracellular thiols and subsequent activation of caspases and PARP cleavage [ 33 ] , responses that would be attenuated by hydrophilic antioxidants.
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