Words similar to caspases
Example sentences for: caspases
How can you use “caspases” in a sentence? Here are some example sentences to help you improve your vocabulary:
Although the requirement for specific caspases was not examined here, it is possible that caspases localized in the Golgi complex (including caspase-2) transduce death signals during the early stages of apoptosis that are associated with fragmentation of specific Golgi proteins.
First, to determine whether a mutation in amino-terminal RING domain of BRCA1 preferentially targeted either the mitochondrial [ 25 ] or Fas/Fas ligand apoptotic pathway [ 24 ] , levels of the respective initiator caspases 9 and 8 were determined.
The loss of cytochrome c causes a break in the electron transfer chain resulting in the production of reactive oxygen species [ 31 ] . Reactive oxygen species are known to cause the oxidation and loss of function of many lipids including cardiolipin [ 20 ] . Finally, caspases activated downstream of cytochrome c release have been implicated in mitochondrial damage [ 29 ] . It appears likely that the cumulative damage of these agents could lead to the irreversible loss of mitochondrial membrane integrity and structure.
24 cells and primary mouse hepatocytes, through activation of the Fas receptor in a FasL-independent manner [ 19 25 ] . Moreover, GCDCA was demonstrated to activate both initiator and effector caspases, and that the apoptotic response can be blocked by Crm A, a caspase 8 inhibitor [ 25 ] . The mechanism by which bile acids stimulate the activation of Fas receptor remains unclear.
The cleavage of calpastatin by caspases initiates the apoptotic cascade in certain neurological disorders [ 20 ] . It is possible that increased expression of calpastatin may control calpain activity thereby limiting extent of proteolysis during capillary sprouting.
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