Words similar to caspase-dependent
Example sentences for: caspase-dependent
How can you use “caspase-dependent” in a sentence? Here are some example sentences to help you improve your vocabulary:
Instead, this amino-terminal mutation favored elevated caspase 3 levels that subsequently facilitated enhanced apoptosis by inactivating the caspase-dependent DNA repair proteins PARP and by inactivating DFF45, an inhibitor of the caspase-dependent DNase, DFF40.
Mancini et al . reported that caspase-2 was localized at the Golgi complex and generated a unique cleavage product of golgin-160 [ 29 ] . Furthermore, these investigators proposed that the Golgi complex transduces proapoptotic signals [ 29 ] . A precedent for this hypothesis was provided by Nakagawa et al ., who reported that caspase-12 is localized to the endoplasmic reticulum and mediates an endoplasmic reticulum-specific apoptosis pathway [ 33 ] . In the present study, we have found that all Golgi autoantigens examined were cleaved in apoptosis in a caspase-dependent manner, as evidenced by studies showing that the pan-caspase inhibitor zVAD-fmk completely blocked the apoptotic fragmentation of these antigens.
Caspase 3 also deactivates vital DNA repair enzymes such as poly ribose ADP polymerase (PARP) [ 27 ] . Cleavage of PARP has been regarded as a hallmark of caspase-dependent apoptosis [ 28 ] .
Our finding that AGE-BSA and PA induce apoptosis through a CD36-mediated and p38- and caspase-dependent mechanism in tubular epithelial cells, similar to TSP-1 and ox-LDL in endothelial cells and macrophages, respectively, suggests that multiple, context-dependent extracellular stimuli of apoptosis may converge on CD36 scavenger receptor to activate src kinase and proapoptotic p38 MAPK pathway.
24 cells to different classes of conjugated bile acids is apparently due to the selective activation of either a PI3K-dependent survival pathway [ 22 23 ] or caspase-dependent death pathway [ 32 ] . Indeed, neither taurine- nor glycine-conjugated bile acids stimulated PI3K activity in CHO.asbt.
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