Words similar to caspase-dependent
Example sentences for: caspase-dependent
How can you use “caspase-dependent” in a sentence? Here are some example sentences to help you improve your vocabulary:
24 cells to different classes of conjugated bile acids is apparently due to the selective activation of either a PI3K-dependent survival pathway [ 22 23 ] or caspase-dependent death pathway [ 32 ] . Indeed, neither taurine- nor glycine-conjugated bile acids stimulated PI3K activity in CHO.asbt.
Instead, this amino-terminal mutation favored elevated caspase 3 levels that subsequently facilitated enhanced apoptosis by inactivating the caspase-dependent DNA repair proteins PARP and by inactivating DFF45, an inhibitor of the caspase-dependent DNase, DFF40.
Our finding that AGE-BSA and PA induce apoptosis through a CD36-mediated and p38- and caspase-dependent mechanism in tubular epithelial cells, similar to TSP-1 and ox-LDL in endothelial cells and macrophages, respectively, suggests that multiple, context-dependent extracellular stimuli of apoptosis may converge on CD36 scavenger receptor to activate src kinase and proapoptotic p38 MAPK pathway.
Mancini et al . reported that caspase-2 was localized at the Golgi complex and generated a unique cleavage product of golgin-160 [ 29 ] . Furthermore, these investigators proposed that the Golgi complex transduces proapoptotic signals [ 29 ] . A precedent for this hypothesis was provided by Nakagawa et al ., who reported that caspase-12 is localized to the endoplasmic reticulum and mediates an endoplasmic reticulum-specific apoptosis pathway [ 33 ] . In the present study, we have found that all Golgi autoantigens examined were cleaved in apoptosis in a caspase-dependent manner, as evidenced by studies showing that the pan-caspase inhibitor zVAD-fmk completely blocked the apoptotic fragmentation of these antigens.
Caspase 3 also deactivates vital DNA repair enzymes such as poly ribose ADP polymerase (PARP) [ 27 ] . Cleavage of PARP has been regarded as a hallmark of caspase-dependent apoptosis [ 28 ] .
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