Words similar to caspases-

Example sentences for: caspases-

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[ 30 ] demonstrated host caspases-8 and -3 to play a role in S. aureus -induced apoptosis, and caspase-8 is known to be associated with apoptosis triggered by engagement of death receptors [ 35 ] . Several recent studies have associated microbial induction of apoptosis with the production of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
A recent report demonstrated that S. aureus -induced apoptosis of epithelial cells involves activation of caspases-8 and-3 [ 30 ] . To determine whether caspase-8 is activated in S. aureus -infected osteoblasts, cultured normal mouse osteoblasts were infected with S. aureus strain UAMS-1 at various MOIs.
Earlier studies have shown that blockade of caspase-8 activation in HeLa cells and deletion of caspase-8 in Jurkat cells prevented activation of downstream signaling, resulting in a failure of the cells to undergo apoptosis in response to TRAIL [ 46 ] . Similarly, another group has demonstrated that apoptosis induced by S. aureus in bovine mammary epithelial (MAC-T) cells utilizes a mechanism involving caspases-8 and -3, which are two key components of the proteolytic cascade that leads to apoptosis [ 30 ] . Results from the current study demonstrate a two-fold increase in caspase-8 activation upon infection with S. aureus (Fig.