Words similar to beta-catenin

Example sentences for: beta-catenin

How can you use “beta-catenin” in a sentence? Here are some example sentences to help you improve your vocabulary:

Beta-catenin then accumulates in the nucleus where it interacts with its transcriptional co-activators, members of the Lymphoid Enhancer Factor/T Cell Factor (LEF/TCF) family of high mobility group DNA binding proteins to regulate gene expression [ 1 ] . Many downstream gene targets of the canonical Wnt/beta-catenin pathway have been identified http://www.stke.org.
Interestingly, mesothelin expression is induced in lung, ovarian, and pancreatic carcinomas where constitutive activation of Wnt signaling is caused by stabilizing mutations in beta-catenin [ 27 28 41 42 43 44 ] . The induction of mesothelin in these carcinomas may be due to misregulation of Wnt signaling as are other targets of the Wnt pathway, c-myc and cyclin D1.
Wnts in this functional class activate the canonical Wnt/beta-catenin pathway (Wnt-1, -3A, and -8).
Much less is understood about Wnt-5a signaling pathway(s) and how Wnt-5a signals are transmitted to the nucleus to affect gene expression compared to the canonical Wnt/beta-catenin signaling pathway.
Mis-regulation of Wnt signaling leads to the development of several human cancers, including colon carcinomas and melanoma [ 1 ] . Canonical Wnt signaling initiates in the binding of a Wnt ligand to its cell surface receptor, members of the frizzled gene family, along with the co-receptor LRP5/6 [ 2 3 ] , leading to changes in the activities of cytoplasmic effectors resulting in the stabilization of beta-catenin protein.