Words similar to beta-catenin

Example sentences for: beta-catenin

How can you use “beta-catenin” in a sentence? Here are some example sentences to help you improve your vocabulary:

Interestingly, Wnt-5a down-regulated mesothelin expression, perhaps through antagonism of endogenous Wnt/beta-catenin signaling.
Beta-catenin then accumulates in the nucleus where it interacts with its transcriptional co-activators, members of the Lymphoid Enhancer Factor/T Cell Factor (LEF/TCF) family of high mobility group DNA binding proteins to regulate gene expression [ 1 ] . Many downstream gene targets of the canonical Wnt/beta-catenin pathway have been identified http://www.stke.org.
, without co-expressing LRP5/6) preferentially activate the Wnt/beta-catenin or Wnt/Ca 2+pathways [ 5 ] . Interestingly, Wnt-5a may couple to either pathway depending on which frizzled receptor is present.
Mis-regulation of Wnt signaling leads to the development of several human cancers, including colon carcinomas and melanoma [ 1 ] . Canonical Wnt signaling initiates in the binding of a Wnt ligand to its cell surface receptor, members of the frizzled gene family, along with the co-receptor LRP5/6 [ 2 3 ] , leading to changes in the activities of cytoplasmic effectors resulting in the stabilization of beta-catenin protein.
A recent report demonstrated that Wnt-5a and Rfz-2 can induce the nuclear localization of the transcription factor NF-AT [ 14 ] . Their results show that NF-AT is a downstream target of the Wnt/Ca 2+pathway and antagonizes the Wnt/beta-catenin pathway in Xenopus embryos.