Example sentences for: akr

How can you use “akr” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Other explanations for the absence of an IPD phenotype in AKXD28 include: inheritance of an AKR/J modifier gene(s) that suppresses the IPD phenotype, a spontaneous reversion of the ipd mutation in AKXD28 mice, or the spontaneous occurrence and fixation of the ipd mutation in strain D2 after the derivation of the AKXD28 strain.

  • Known characteristics of the AKR/J and D2 strains offer few clues to AKXD28's increased susceptibility to pressure-induced damage and all explanatory attempts are speculative.

  • AKXD28 mice, therefore, have a genetic background that is a mix of the D2 (glaucomatous) and AKR/J (normal eyes with no obvious disease) genomes.

  • It includes Far1p, a protein necessary for pheromone-induced cell cycle arrest in G1 [ 11 ] , Mpt5p, a protein necessary for recovery from cell cycle arrest [ 12 ] , and Bem1p and Sph1, both of which are necessary for establishment of cell polarity during shmooing and budding [ 13 14 ] . In our protein-interaction map there is no direct interaction between a pheromone receptor (Ste2p or Ste3p) and any component of the heterotrimeric G protein complex (Ste4p/Ste18p/Gpa1p), so NetSearch drew indirect paths through Akr1p, a known inhibitor of signaling in the pheromone pathway [ 15 ] . The predicted network does not include the GTPase Cdc42p (paths were instead drawn preferentially through its cofactor Cdc24p, which physically interacts with Ste4p) or Ste20p, because of missing interactions in the protein-interaction map.

  • Interestingly, AKR/J airways have a strain specific hyper-responsive reaction to intravenously injected PAF [ 51].


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