Example sentences for: akaps

How can you use “akaps” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It has been known for the past decade that compartmentalization of PKA can occur through association with A-kinase anchoring proteins (AKAPs).

  • It appears that several AKAPs may be in close proximity; yet, it still needs to be determined if waves of cAMP would turn on signals in a local or global way.

  • Tables 1and 2summarize the compartmental localization and mitochondrial association in the NMJ and intercostal muscle of the several AKAPs and kinases studied based on the immunofluorescence work reported here.

  • Selected AKAPs have been identified that can interact with both PKA and PKC [ 12 13 ] . For example, it was shown that AKAP 79 maintains PKA, PKC, and protein phosphatase 2B at the postsynaptic density of mammalian synapses [ 14 12 ] . Likewise, gravin, a second PKA/PKC anchoring protein, targets these kinases to the membrane cytoskeleton [ 13 ] . AKAP79, gravin, and its mouse homolog clone 72 thus belong to the recently identified class of scaffolding proteins that coordinate multiple kinase activity by bringing them to one site.

  • Differential compartmentation of these signaling molecules in cells and tissues is being recognized as a mechanism to regulate their specificity [reviewed recently by [ 6 ] ]. A Kinase Anchoring Proteins (AKAPs) can direct their subcellular localization by binding directly to regulatory subunits of PKA or to the catalytic core of PKC.

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