Example sentences for: akaps

How can you use “akaps” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It has been known for the past decade that compartmentalization of PKA can occur through association with A-kinase anchoring proteins (AKAPs).

  • However, a new class of AKAPs was discovered when two dual-specific AKAPs (D-AKAP1 and D-AKAP2) were cloned using a fusion protein of the RIα as the bait in a yeast two-hybrid screen [ 15 16 ] ). Therefore, the contrasted distribution pattern between RI and RII may in part be due to selective association with different compartmentalized pools of AKAPs.

  • Because we produced antibodies to two novel dual-specific AKAPs (D-AKAP1 and D-AKAP2), and gravin, we were uniquely positioned to use immunofluorescence to investigate their possible roles in kinase signaling in and around the NMJ.

  • Many AKAPs have been identified, although information about their subcellular distribution in different tissues is largely lacking.

  • Selected AKAPs have been identified that can interact with both PKA and PKC [ 12 13 ] . For example, it was shown that AKAP 79 maintains PKA, PKC, and protein phosphatase 2B at the postsynaptic density of mammalian synapses [ 14 12 ] . Likewise, gravin, a second PKA/PKC anchoring protein, targets these kinases to the membrane cytoskeleton [ 13 ] . AKAP79, gravin, and its mouse homolog clone 72 thus belong to the recently identified class of scaffolding proteins that coordinate multiple kinase activity by bringing them to one site.


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