Words similar to akaps

Example sentences for: akaps

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Many AKAPs have been identified, although information about their subcellular distribution in different tissues is largely lacking.
Several large coiled-coil proteins were also found associated with the cytoplasmic surface of the Golgi apparatus, and two of them have been shown to function in the docking of vesicles to the Golgi cisternae [ 16 17 18 ] . AKAPs are adapter proteins that attach protein kinase PKA pathways to cytoskeletal elements.
Selected AKAPs have been identified that can interact with both PKA and PKC [ 12 13 ] . For example, it was shown that AKAP 79 maintains PKA, PKC, and protein phosphatase 2B at the postsynaptic density of mammalian synapses [ 14 12 ] . Likewise, gravin, a second PKA/PKC anchoring protein, targets these kinases to the membrane cytoskeleton [ 13 ] . AKAP79, gravin, and its mouse homolog clone 72 thus belong to the recently identified class of scaffolding proteins that coordinate multiple kinase activity by bringing them to one site.
However, a new class of AKAPs was discovered when two dual-specific AKAPs (D-AKAP1 and D-AKAP2) were cloned using a fusion protein of the RIα as the bait in a yeast two-hybrid screen [ 15 16 ] ). Therefore, the contrasted distribution pattern between RI and RII may in part be due to selective association with different compartmentalized pools of AKAPs.
The work reported here was undertaken to further understand the compartmentalization of PKA and PKC through association with AKAPs.