Example sentences for: akaps

How can you use “akaps” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It appears that several AKAPs may be in close proximity; yet, it still needs to be determined if waves of cAMP would turn on signals in a local or global way.

  • Selected AKAPs have been identified that can interact with both PKA and PKC [ 12 13 ] . For example, it was shown that AKAP 79 maintains PKA, PKC, and protein phosphatase 2B at the postsynaptic density of mammalian synapses [ 14 12 ] . Likewise, gravin, a second PKA/PKC anchoring protein, targets these kinases to the membrane cytoskeleton [ 13 ] . AKAP79, gravin, and its mouse homolog clone 72 thus belong to the recently identified class of scaffolding proteins that coordinate multiple kinase activity by bringing them to one site.

  • However, a recent study showing the colocalization of D-AKAP1 with RI at the NMJ supports the prediction that localization of the R subunit there requires interaction with an AKAP [ 17 ] . RII has been shown to be associated with mAKAP in heart and skeletal muscle [ 20 21 ] ; however, little is known regarding the expression patterns of RII and AKAPs in the perijunctional regions.

  • Because we produced antibodies to two novel dual-specific AKAPs (D-AKAP1 and D-AKAP2), and gravin, we were uniquely positioned to use immunofluorescence to investigate their possible roles in kinase signaling in and around the NMJ.

  • Many AKAPs have been identified, although information about their subcellular distribution in different tissues is largely lacking.


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