Example sentences for: akaps

How can you use “akaps” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • For PKA binding, it was thought for a long time that only RII subunits bind to AKAPs.

  • Differential compartmentation of these signaling molecules in cells and tissues is being recognized as a mechanism to regulate their specificity [reviewed recently by [ 6 ] ]. A Kinase Anchoring Proteins (AKAPs) can direct their subcellular localization by binding directly to regulatory subunits of PKA or to the catalytic core of PKC.

  • It has been known for the past decade that compartmentalization of PKA can occur through association with A-kinase anchoring proteins (AKAPs).

  • Several large coiled-coil proteins were also found associated with the cytoplasmic surface of the Golgi apparatus, and two of them have been shown to function in the docking of vesicles to the Golgi cisternae [ 16 17 18 ] . AKAPs are adapter proteins that attach protein kinase PKA pathways to cytoskeletal elements.

  • Selected AKAPs have been identified that can interact with both PKA and PKC [ 12 13 ] . For example, it was shown that AKAP 79 maintains PKA, PKC, and protein phosphatase 2B at the postsynaptic density of mammalian synapses [ 14 12 ] . Likewise, gravin, a second PKA/PKC anchoring protein, targets these kinases to the membrane cytoskeleton [ 13 ] . AKAP79, gravin, and its mouse homolog clone 72 thus belong to the recently identified class of scaffolding proteins that coordinate multiple kinase activity by bringing them to one site.


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