Example sentences for: akaps

How can you use “akaps” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The work reported here was undertaken to further understand the compartmentalization of PKA and PKC through association with AKAPs.

  • Several large coiled-coil proteins were also found associated with the cytoplasmic surface of the Golgi apparatus, and two of them have been shown to function in the docking of vesicles to the Golgi cisternae [ 16 17 18 ] . AKAPs are adapter proteins that attach protein kinase PKA pathways to cytoskeletal elements.

  • It has been known for the past decade that compartmentalization of PKA can occur through association with A-kinase anchoring proteins (AKAPs).

  • However, a recent study showing the colocalization of D-AKAP1 with RI at the NMJ supports the prediction that localization of the R subunit there requires interaction with an AKAP [ 17 ] . RII has been shown to be associated with mAKAP in heart and skeletal muscle [ 20 21 ] ; however, little is known regarding the expression patterns of RII and AKAPs in the perijunctional regions.

  • Selected AKAPs have been identified that can interact with both PKA and PKC [ 12 13 ] . For example, it was shown that AKAP 79 maintains PKA, PKC, and protein phosphatase 2B at the postsynaptic density of mammalian synapses [ 14 12 ] . Likewise, gravin, a second PKA/PKC anchoring protein, targets these kinases to the membrane cytoskeleton [ 13 ] . AKAP79, gravin, and its mouse homolog clone 72 thus belong to the recently identified class of scaffolding proteins that coordinate multiple kinase activity by bringing them to one site.

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