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Example sentences for: akaps

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Several large coiled-coil proteins were also found associated with the cytoplasmic surface of the Golgi apparatus, and two of them have been shown to function in the docking of vesicles to the Golgi cisternae [ 16 17 18 ] . AKAPs are adapter proteins that attach protein kinase PKA pathways to cytoskeletal elements.
Tables 1and 2summarize the compartmental localization and mitochondrial association in the NMJ and intercostal muscle of the several AKAPs and kinases studied based on the immunofluorescence work reported here.
For PKA binding, it was thought for a long time that only RII subunits bind to AKAPs.
However, a new class of AKAPs was discovered when two dual-specific AKAPs (D-AKAP1 and D-AKAP2) were cloned using a fusion protein of the RIα as the bait in a yeast two-hybrid screen [ 15 16 ] ). Therefore, the contrasted distribution pattern between RI and RII may in part be due to selective association with different compartmentalized pools of AKAPs.
It appears that several AKAPs may be in close proximity; yet, it still needs to be determined if waves of cAMP would turn on signals in a local or global way.