Words similar to akap
Example sentences for: akap
How can you use “akap” in a sentence? Here are some example sentences to help you improve your vocabulary:
Of the 7 kinase and AKAP labeling patterns shown in this paper, RIIα is the only one that strongly associates with the z-line (contrast with the phalloidin labeling shown in fig.
However, a recent study showing the colocalization of D-AKAP1 with RI at the NMJ supports the prediction that localization of the R subunit there requires interaction with an AKAP [ 17 ] . RII has been shown to be associated with mAKAP in heart and skeletal muscle [ 20 21 ] ; however, little is known regarding the expression patterns of RII and AKAPs in the perijunctional regions.
We also investigated the distribution of gravin at the NMJ because this AKAP is an autoantigen for myasthenia gravis, a degenerative disease of the NMJ.
Consistent with the observed mitochondrial staining by anti-D-AKAP1, it was shown previously that one of the two alternative NH2-terminal motifs of this AKAP is necessary and sufficient for targeting to mitochondria [ 28 ] . Interestingly, another AKAP governs voltage-dependent potentiation of L-type calcium channels through anchoring of PKA in transverse tubules [ 36 ] . Because this potentiation is not dependent on RIIα, it is thought that RIα is capable of this AKAP-directed modulation of calcium channel activity [ 37 ] .
This observation is supported by previous work that demonstrated RIα codistribution with nAChR [ 19 ] and D-AKAP1 [ 17 ] suggesting that this AKAP is the anchoring protein recruiting RIα to this membrane.
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