Words similar to ala
Example sentences for: ala
How can you use “ala” in a sentence? Here are some example sentences to help you improve your vocabulary:
To address this issue, we used the following mutant versions of Boi1: the "S" mutant, which contains a Lys residue in place of a Trp residue at a highly conserved position in the SH3 domain; the "P" mutant, in which seven of the nine Pro residues in the Pro-rich region are replaced with Ala residues (a version of Boi1 that does not bind Bem1); and the "SP" mutant, which contains both the "S" and "P" changes [ 1 ] .
In order to illustrate how, based on our models, a high affinity ligand can be rationally designed to be specific for beta2-containing nAChR subtypes, we searched a database of over 200,000 compounds (ChemDiv Inc., San Diego, CA), for alpha4-beta2 ligand candidates presenting a functional group close to Ala 135 of the beta2 subunit, hoping that such functional group could not accommodate the bulkier Leu 135 of beta4 (Figure 4- Top).
The same result was obtained when p66 INSwas dimerized with p51 having Asp→Ala mutation at amino acid position 186 (one of the catalytically crucial carboxylate triad) but having an intact β7-β8 loop.
However, there are many case reports describing patients with progressive neurodegenerative disorders of unknown etiology, collectively referred to as neuronal intranuclear inclusion disease [ 77 ] . While these may consist mainly of unidentified poly-Gln or poly-Ala disorders, the present study raises the possibility that some forms of this disease may arise through unexpected mechanisms, perhaps involving mutations in Rab24 or other poorly characterized members of the Rab GTPase family that mediate trafficking of misfolded proteins within autophagosomes and lysosomes.
C ash surplus/d eficit H o s pital Insura nce trus t fund b ala nc e
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