Example sentences for: akt

How can you use “akt” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • All three human members of the AKT family are over-produced in various human cancers.

  • Although the molecular signaling mechanisms that transduce the effects of phasic patterns of work activity to modify muscle mass are incompletely understood, recent evidence implicates pathways that include the signaling molecules PI3 kinase, Akt, mTOR, S6K, and ERK, the ubiquitin ligases MAFbx and MuRF1, and transcription factors of the FOX superfamily in the control of both catabolic and anabolic processes [21,22,23,24].

  • Tumors that were Wnt-1 TG, Pten +/- with LOH displayed staining of phosphorylated AKT (Fig.

  • First, PTEN's protein phosphatase activity is able to down-regulate focal adhesion kinase (FAK) phosphorylation, which leads to the inactivation of the Ras/MAP kinase pathway [ 19 20 21 ] . Second, its lipid phosphatase activity targets the second messenger phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P 3 ] and thereby blocks activation of the protein kinase B (PKB/Akt) pathway [ 11 18 22 23 24 ] . Whereas both of the above pathways are intimately involved in the control of cell growth and survival, PTEN-regulated FAK activity further appears to impinge on cell adhesion, cell migration, and cell invasion [ 20 21 ] . It therefore emerges that the loss of PTEN activity may confer increased survival ability, proliferative potential, and invasive capacity on cells, and thereby may promote progression towards a more malignant phenotype.

  • PTEN -deficient human and mouse cells have elevated levels of intracellular PtdIns(3,4,5)P3 [ 10, 11] and demonstrate constitutive activation of AKT in the absence of growth factors [ 12, 13, 14].


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