Example sentences for: akt

How can you use “akt” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • [for reviews see refs [ 31 ] , [ 39 40 41 ] ]. The IGF-IR appears to function in transformation both by preventing apoptosis through activation of Akt and by stimulating proliferation through the ras-MAPK cascade.

  • Inactivation of Pten promotes membrane recruitment of AKT and its subsequent activation by phosphorylation at Ser473 and Thr308 [ 10, 11, 13].

  • Constitutive membrane localization of AKT leads to its deregulated activation and can induce oncogenic transformation [ 8, 9].

  • This result may seem paradoxical since increased phosphorylated AKT, due to inactivation of Pten , suppresses apoptosis and promotes proliferation.

  • The PI-3Kinase-dependent activation of Akt is thought to play a central role in the cell survival pathway in many cells [ 7 19 20 ] . Elevated Akt activity and protein is found in many PTEN-deficient cancer cells.


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