Example sentences for: akt

How can you use “akt” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This result may seem paradoxical since increased phosphorylated AKT, due to inactivation of Pten , suppresses apoptosis and promotes proliferation.

  • Several apoptotic pathways may be inhibited upon activation of AKT, promoting maintenance and survival of tumor cells.

  • Substrates of AKT include glycogen synthase kinase 3 (GSK3), p70/S6 kinase, BAD, Caspase 9, 4E-BP1, IκB kinase α and members of the Forkhead transcription family [reviewed in ref.

  • Membrane localization renders AKT permissive to phosphorylation by phosphatidyl inositol-dependent kinases, PDK1 and PDK2, at Thr308 within the activation loop and at Ser473 near the carboxyl terminus.

  • To determine if activated AKT was increased in tumors that had a Pten defect, these sections were stained using an antibody that specifically detects AKT1 phosphorylated at Ser 473 (and AKT2 and AKT3 phosphorylated at equivalent sites).


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