Example sentences for: akt

How can you use “akt” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This glioma is deficient in PTEN and shows constitutive activation of Akt, which can be inactivated by re-introduction of PTEN [ 47 ] .

  • All three human isoforms of AKT have been found to be deregulated in human breast cancer cells [ 32, 33, 34].

  • AKT1 is over-expressed in gastric adenocarcinomas and breast cancer cell lines, AKT2 is amplified and over-expressed in pancreatic, ovarian, and breast cancers, and AKT3 is upregulated in estrogen receptor-deficient breast cancer and in androgen-independent prostate cell lines [reviewed in ref.

  • To determine if activated AKT was increased in tumors that had a Pten defect, these sections were stained using an antibody that specifically detects AKT1 phosphorylated at Ser 473 (and AKT2 and AKT3 phosphorylated at equivalent sites).

  • The presence of areas unstained with antibody specific for phosphorylated AKT suggests that additional factors other than Pten may influence the activation of AKT.


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