Words similar to akt

Example sentences for: akt

How can you use “akt” in a sentence? Here are some example sentences to help you improve your vocabulary:

PTEN is altered or deleted in many human cancers [ 7 8 9 10 ] . In-vitro, cells that are deficient in PTEN show elevated PI-3Kinase signaling [ 11 ] . Reintroduction of PTEN in a variety of cancer cells, including glioma, breast, bladder and ovarian cancer cells, causes G1 arrest, inhibits tumorigenesis, and promotes anoikis [ 12 13 14 ] . Mechanistically, Akt activity is decreased, cell motility is decreased, expression of two cyclin-dependent kinase inhibitors p27 and p21 is increased, cyclin D1 is down-regulated, Rb phosphorylation is inhibited, and signaling via Grb2/SOS is suppressed [ 11 15 ] . The link between PTEN and cell growth is underscored by genetic experiments in mice.
42] can be used to introduce viral vectors carrying genes encoding an activated form of PI3K, AKT, or candidate substrates for AKT into the mammary tissue of Wnt-1 TG mice.
This glioma is deficient in PTEN and shows constitutive activation of Akt, which can be inactivated by re-introduction of PTEN [ 47 ] .
This result may seem paradoxical since increased phosphorylated AKT, due to inactivation of Pten , suppresses apoptosis and promotes proliferation.
The PI-3Kinase-dependent activation of Akt is thought to play a central role in the cell survival pathway in many cells [ 7 19 20 ] . Elevated Akt activity and protein is found in many PTEN-deficient cancer cells.