Words similar to akt

Example sentences for: akt

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The figure also introduces two derivatives of the 'molecule' icon: a 'dimer' icon (adapted from Kohn [ 6]) to represent dimers such as cyclin D1-Cdk4 and a 'biomolecule' icon as a shorthand to represent catalytically active molecules with both 'concentration' and 'activity' properties (for example the kinases in the mitogen-to-ERK and -Akt kinase cascades).
Inactivation of Pten promotes membrane recruitment of AKT and its subsequent activation by phosphorylation at Ser473 and Thr308 [ 10, 11, 13].
Akt directly phosphorylates and inactivates the pro-apoptotic proteins ASK1, BAD, caspase 9 [ 21 22 23 24 ] . Akt also induces the expression of the anti-apoptotic Bcl-2 and c-FLIP proteins, and suppresses the cell cycle inhibitor p27 KIP [ 25 26 27 28 ] . This later effect is via the phosphorylation and inactivation of the forkhead family of transcription factors AFX, FKHR and FKHR-L1.
Constitutive membrane localization of AKT leads to its deregulated activation and can induce oncogenic transformation [ 8, 9].
PTEN -deficient human and mouse cells have elevated levels of intracellular PtdIns(3,4,5)P3 [ 10, 11] and demonstrate constitutive activation of AKT in the absence of growth factors [ 12, 13, 14].