Words similar to akt

Example sentences for: akt

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Akt directly phosphorylates and inactivates the pro-apoptotic proteins ASK1, BAD, caspase 9 [ 21 22 23 24 ] . Akt also induces the expression of the anti-apoptotic Bcl-2 and c-FLIP proteins, and suppresses the cell cycle inhibitor p27 KIP [ 25 26 27 28 ] . This later effect is via the phosphorylation and inactivation of the forkhead family of transcription factors AFX, FKHR and FKHR-L1.
Although it is often assumed that elevated Akt activity is responsible for the increased survival of cancer cells, Akt activity is not the only pathway that is essential for cell survival.
The figure also introduces two derivatives of the 'molecule' icon: a 'dimer' icon (adapted from Kohn [ 6]) to represent dimers such as cyclin D1-Cdk4 and a 'biomolecule' icon as a shorthand to represent catalytically active molecules with both 'concentration' and 'activity' properties (for example the kinases in the mitogen-to-ERK and -Akt kinase cascades).
This result may seem paradoxical since increased phosphorylated AKT, due to inactivation of Pten , suppresses apoptosis and promotes proliferation.
All three human isoforms of AKT have been found to be deregulated in human breast cancer cells [ 32, 33, 34].