Example sentences for: akt

How can you use “akt” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This approach has been successful in producing conditional forms of the Tec family PTK Bmx [ 22], and also the PTKs v-Src [ 23], Hck [ 24] and Abl [ 25], the serine/threonine kinases Raf [ 26] and Akt [ 27], and the dual specificity protein kinase MEK1 [ 23].

  • The PI-3Kinase-dependent activation of Akt is thought to play a central role in the cell survival pathway in many cells [ 7 19 20 ] . Elevated Akt activity and protein is found in many PTEN-deficient cancer cells.

  • As expected, phosphorylated AKT was undetectable in hyperplastic ducts, in tumors from Wnt-1 TG, Pten +/+ mice, and tumors from Wnt-1 TG, Pten +/- mice that retained the wild type allele (Fig.

  • This result may seem paradoxical since increased phosphorylated AKT, due to inactivation of Pten , suppresses apoptosis and promotes proliferation.

  • AKT1 is over-expressed in gastric adenocarcinomas and breast cancer cell lines, AKT2 is amplified and over-expressed in pancreatic, ovarian, and breast cancers, and AKT3 is upregulated in estrogen receptor-deficient breast cancer and in androgen-independent prostate cell lines [reviewed in ref.


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