Example sentences for: akt

How can you use “akt” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Constitutive membrane localization of AKT leads to its deregulated activation and can induce oncogenic transformation [ 8, 9].

  • PTEN -deficient human and mouse cells have elevated levels of intracellular PtdIns(3,4,5)P3 [ 10, 11] and demonstrate constitutive activation of AKT in the absence of growth factors [ 12, 13, 14].

  • 42] can be used to introduce viral vectors carrying genes encoding an activated form of PI3K, AKT, or candidate substrates for AKT into the mammary tissue of Wnt-1 TG mice.

  • Inactivation of Pten promotes membrane recruitment of AKT and its subsequent activation by phosphorylation at Ser473 and Thr308 [ 10, 11, 13].

  • To determine if activated AKT was increased in tumors that had a Pten defect, these sections were stained using an antibody that specifically detects AKT1 phosphorylated at Ser 473 (and AKT2 and AKT3 phosphorylated at equivalent sites).


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