Example sentences for: akt

How can you use “akt” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • All three human members of the AKT family are over-produced in various human cancers.

  • This approach has been successful in producing conditional forms of the Tec family PTK Bmx [ 22], and also the PTKs v-Src [ 23], Hck [ 24] and Abl [ 25], the serine/threonine kinases Raf [ 26] and Akt [ 27], and the dual specificity protein kinase MEK1 [ 23].

  • Akt directly phosphorylates and inactivates the pro-apoptotic proteins ASK1, BAD, caspase 9 [ 21 22 23 24 ] . Akt also induces the expression of the anti-apoptotic Bcl-2 and c-FLIP proteins, and suppresses the cell cycle inhibitor p27 KIP [ 25 26 27 28 ] . This later effect is via the phosphorylation and inactivation of the forkhead family of transcription factors AFX, FKHR and FKHR-L1.

  • [for reviews see refs [ 31 ] , [ 39 40 41 ] ]. The IGF-IR appears to function in transformation both by preventing apoptosis through activation of Akt and by stimulating proliferation through the ras-MAPK cascade.

  • 42] can be used to introduce viral vectors carrying genes encoding an activated form of PI3K, AKT, or candidate substrates for AKT into the mammary tissue of Wnt-1 TG mice.


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