Example sentences for: akt

How can you use “akt” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Phosphorylation activates the kinase domain of AKT, which, in turn, phosphorylates target proteins on serine and threonine residues.

  • The significance of HGF/SF as a marker of poor prognosis might also be associated with its effects on acquired resistance to anti-cancer drugs [ 35 36 ] . HGF/SF protects cancer cells from DNA-damaging chemotherapy agents through pathways involving signaling from Met to phosphoinositide 3-kinase and c-Akt [ 29 ] . Human breast cancer cells, preincubated with HGF/SF and then exposed to Adriamycin, exhibit an altered pattern of gene expression compared with cells treated with Adriamycin alone.

  • PTEN is altered or deleted in many human cancers [ 7 8 9 10 ] . In-vitro, cells that are deficient in PTEN show elevated PI-3Kinase signaling [ 11 ] . Reintroduction of PTEN in a variety of cancer cells, including glioma, breast, bladder and ovarian cancer cells, causes G1 arrest, inhibits tumorigenesis, and promotes anoikis [ 12 13 14 ] . Mechanistically, Akt activity is decreased, cell motility is decreased, expression of two cyclin-dependent kinase inhibitors p27 and p21 is increased, cyclin D1 is down-regulated, Rb phosphorylation is inhibited, and signaling via Grb2/SOS is suppressed [ 11 15 ] . The link between PTEN and cell growth is underscored by genetic experiments in mice.

  • The PI-3Kinase-dependent activation of Akt is thought to play a central role in the cell survival pathway in many cells [ 7 19 20 ] . Elevated Akt activity and protein is found in many PTEN-deficient cancer cells.

  • All three human isoforms of AKT have been found to be deregulated in human breast cancer cells [ 32, 33, 34].


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