Example sentences for: active-controlled

How can you use “active-controlled” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • A double-blind, active-controlled hypertension component is designed to compare the rate of fatal coronary heart disease (CHD) or nonfatal myocardial infarction (MI) (the primary endpoint) in high-risk hypertensive participants, aged 55 years or older, between those randomized to treatment initiated with a diuretic (chlorthalidone) and treatment initiated with each of three alternative antihypertensive drugs: a calcium-channel blocker (amlodipine), an angiotensin-converting enzyme (ACE)-inhibitor (lisinopril), or an alpha-adrenergic blocker (doxazosin).

  • Thus, the use of placebo is typically presumed “guilty until proven innocent,” while active-controlled designs are presumed “innocent until proven guilty.”

  • Armed with such evidence—whether it qualifies aspirin as “proven therapy” is open to subjective interpretation—many placebo opponents, we maintain, would argue for an active-controlled design as a more ethical alternative to the placebo-controlled design actually used in APPROVe [11].

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