Words similar to activators
Example sentences for: activators
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LM-PCR has been used in several studies, including a systematic genome-wide location analysis of yeast transcriptional activators [ 10 ] , and an unbiased search for E2F binding sites in a subset of human promoters [ 11 ] . Studies employing the R-PCR approach include genome-wide analyses of silencing enzymes [ 12 ] and histone modifications [ 6 7 ] in yeast, and a mapping of GATA-1 binding sites within the human β-globin locus [ 13 ] .
Phorbol esters are often used as activators of PKC to investigate the role of the kinase in cellular functions [ 1 ] . Accumulating lines of evidence indicates that PMA plays a complex role in regulation of cellular function, including PKC-dependent [ 18 19 20 ] and PKC-independent ways [ 23 24 21 ] . In the present results, PMA inhibited slow membrane depolarization and action potentials in response to glucose stimulation (Fig.
found 8-mer activators, though none was tested for modularity [ 21 ] . Nonetheless, the tendency for C-terminal activators to be longer than the average library peptide suggests a preference for length in the transactivation function [ 24 ] .
Indeed, as P-TEFb is a coactivator of potent activators that mediate effects of enhancers and can itself activate transcription when placed on sites distal to promoter elements [15], it might mediate many more signaling events than those of heat shock, ultraviolet light, stress, and hypertrophy.
The proto-oncogene TEL (Translocation, Ets, Leukemia) is a transcriptional repressor that contains a C-terminal Ets family DNA binding domain; a central domain that together with co-repressors recruit histone deacetylases [ 1 2 3 ] ; and an N-terminal SAM (sterile, alpha, motif) domain [ 4 5 6 ] , which we have recently shown forms a polymer [ 7 ] . Chromosomal translocations in a variety of leukemias result in fusion of the SAM domain of TEL to tyrosine kinase domains such as ABL, PDGFβ and JAK2 [ 8 9 10 11 12 13 14 ] or to the transcriptional activators AML1 and ARNT [ 15 16 17 ] . In the tyrosine kinase fusions, SAM domain polymerization leads to constitutive activation of the tyrosine kinase domains, which leads in turn to cell transformation [ 10 12 18 19 ] . Thus, compounds that block TEL-SAM polymerization could be effective in treating these leukemias.
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