Words similar to activators
Example sentences for: activators
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The action is mediated by specific nuclear receptor proteins, which belong to a superfamily of ligand-modulated transcription factors that regulate homeostasis, reproduction, development, and differentiation [ 87 ] . This family includes receptors for steroid hormones, thyroid hormones, hormonal forms of vitamin A and D, peroxisomal activators, and ecdysone [ 88 ] . Nuclear hormone receptors are ligand-dependent transcription factors that regulate genes critical to such biological processes as development, reproduction, and homeostasis.
Along this line, Draper et al [ 5 ] observed that the two transactivation domains present in the yCCR4 N-terminus (residues 1 to 350) are, alone, more potent activators than within the full-length yCCR4 protein.
However, structural features such as acidity observed in previous studies were not absolute requirements for activation [ 11 20 21 ] . Charge neutral and basic peptide activators arose at significant frequencies.
Retests confirmed 100% (16/16) as true activators.
These include: a Hh-protein-blocking antibody, 5E1 [ 23 ] ; a natural product derivative, cyclopamine [ 9 10 ] that has recently been shown to act downstream of Ptc, perhaps at the level of Smo [ 11 ] ; a recently identified synthetic small-molecule inhibitor, Cur61414, which has inhibitory properties similar to cyclopamine [ 17 ] ; and forskolin, an adenylate cyclase/protein kinase A activator that is thought to block Hh signaling by stimulating degradation of members of the Gli family of transcriptional activators [ 2 ] .
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