Example sentences for: activators

How can you use “activators” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The effect of PKC activators PMA and Bryostatin 1 on IFNg inducibility of MHCII in three resistant tumor cell lines of different histological origin has been examined.

  • When two sequences with +1 frameshifted inserts were picked from the unselected random peptide library, both behaved as activators (not shown).

  • Members of the AP-1 family of transcription factors are essential transcriptional activators for both the MMP-1 and MMP-13 genes [ 25, 26, 27], and these transcription factors are activated by extracellular stimuli through MAPK pathways [ 28].

  • However, structural features such as acidity observed in previous studies were not absolute requirements for activation [ 11 20 21 ] . Charge neutral and basic peptide activators arose at significant frequencies.

  • The proto-oncogene TEL (Translocation, Ets, Leukemia) is a transcriptional repressor that contains a C-terminal Ets family DNA binding domain; a central domain that together with co-repressors recruit histone deacetylases [ 1 2 3 ] ; and an N-terminal SAM (sterile, alpha, motif) domain [ 4 5 6 ] , which we have recently shown forms a polymer [ 7 ] . Chromosomal translocations in a variety of leukemias result in fusion of the SAM domain of TEL to tyrosine kinase domains such as ABL, PDGFβ and JAK2 [ 8 9 10 11 12 13 14 ] or to the transcriptional activators AML1 and ARNT [ 15 16 17 ] . In the tyrosine kinase fusions, SAM domain polymerization leads to constitutive activation of the tyrosine kinase domains, which leads in turn to cell transformation [ 10 12 18 19 ] . Thus, compounds that block TEL-SAM polymerization could be effective in treating these leukemias.


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