Words similar to active-site
Example sentences for: active-site
How can you use “active-site” in a sentence? Here are some example sentences to help you improve your vocabulary:
Before this study, structure determination, biochemical studies and sequence comparisons of 2OG-Fe(II) dioxygenases [ 1, 9] had elucidated their structural fold, active-site residues and reaction mechanism.
Although human biochemists can depress activity more than 10 5-fold in Fhit [ 35, 36] and Hint [ 30] with a single active-site His mutation, hens apparently continued to peck at the sequence of Hint, altering all four of the absolutely conserved His residues.
This, together with the phyletic distributution of the AraC and 2OG-Fe(II) dioxygenase superfamilies, leads us to speculate that the 2OG-Fe(II) dioxygenase superfamily evolved from the AraC-like superfamily in bacteria through drastic sequence divergence that eliminated significant sequence similarity, followed by fixation of the modified active-site configuration.
This reduction was active-site dependent: adding back multicopy HNT2 with the nucleophilic histidine replaced by alanine or aspartate reduced dinucleoside polyphosphate levels less than two-fold.
It exhibits signature motifs corresponding to the regions of the active-site lysine and the interdomain interface [ 3].