Example sentences for: active-site

How can you use “active-site” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • As expected, transfection of cells with DHBV DNA carrying the YMHA polymerase active-site mutant ablated all DNA synthesis (lanes 4 and 8).

  • It exhibits signature motifs corresponding to the regions of the active-site lysine and the interdomain interface [ 3].

  • Although human biochemists can depress activity more than 10 5-fold in Fhit [ 35, 36] and Hint [ 30] with a single active-site His mutation, hens apparently continued to peck at the sequence of Hint, altering all four of the absolutely conserved His residues.

  • This reduction was active-site dependent: adding back multicopy HNT2 with the nucleophilic histidine replaced by alanine or aspartate reduced dinucleoside polyphosphate levels less than two-fold.

  • Furthermore, the active-site mutant alleles of HNT2 , HNT2-His109Ala and HNT2-His109Asp , provided on plasmids pB32 and pB86, demonstrated intermediate abilities to control dinucleoside polyphosphate levels, suggesting that elevated temperature reduces the catalytic defects of these mutant enzymes.


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