Words similar to active-site
Example sentences for: active-site
How can you use “active-site” in a sentence? Here are some example sentences to help you improve your vocabulary:
The KilA-N, APSES and TEN-terminal domains lack the equivalent residues of the specific active-site extension of the LAGLIDADG nucleases, suggesting that the former domains do not possess nuclease activity.
This, together with the phyletic distributution of the AraC and 2OG-Fe(II) dioxygenase superfamilies, leads us to speculate that the 2OG-Fe(II) dioxygenase superfamily evolved from the AraC-like superfamily in bacteria through drastic sequence divergence that eliminated significant sequence similarity, followed by fixation of the modified active-site configuration.
Here, using sequence profile searches, we show that many other protein families contain the same constellation of active-site residues and are predicted to adopt the same fold.
Furthermore, the active-site mutant alleles of HNT2 , HNT2-His109Ala and HNT2-His109Asp , provided on plasmids pB32 and pB86, demonstrated intermediate abilities to control dinucleoside polyphosphate levels, suggesting that elevated temperature reduces the catalytic defects of these mutant enzymes.
Although human biochemists can depress activity more than 10 5-fold in Fhit [ 35, 36] and Hint [ 30] with a single active-site His mutation, hens apparently continued to peck at the sequence of Hint, altering all four of the absolutely conserved His residues.
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