Example sentences for: active-site

How can you use “active-site” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • As expected, transfection of cells with DHBV DNA carrying the YMHA polymerase active-site mutant ablated all DNA synthesis (lanes 4 and 8).

  • This, together with the phyletic distributution of the AraC and 2OG-Fe(II) dioxygenase superfamilies, leads us to speculate that the 2OG-Fe(II) dioxygenase superfamily evolved from the AraC-like superfamily in bacteria through drastic sequence divergence that eliminated significant sequence similarity, followed by fixation of the modified active-site configuration.

  • This reduction was active-site dependent: adding back multicopy HNT2 with the nucleophilic histidine replaced by alanine or aspartate reduced dinucleoside polyphosphate levels less than two-fold.

  • Here, using sequence profile searches, we show that many other protein families contain the same constellation of active-site residues and are predicted to adopt the same fold.

  • Furthermore, the active-site mutant alleles of HNT2 , HNT2-His109Ala and HNT2-His109Asp , provided on plasmids pB32 and pB86, demonstrated intermediate abilities to control dinucleoside polyphosphate levels, suggesting that elevated temperature reduces the catalytic defects of these mutant enzymes.


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