Words similar to ynot
Example sentences for: ynot
How can you use “ynot” in a sentence? Here are some example sentences to help you improve your vocabulary:
Indeed, both human homologs of yPOP2, hCAF1 and hPOP2, lack the 148 N-terminal amino acids which are, in yPOP2, required for transcriptional activation, whereas the yPOP2 C-terminus, which is involved in the interaction with yCCR4, is conserved in hCAF1 [ 11 ] and hPOP2 [ 19 ] . Similarly, hNOT2, the human homolog of the yNOT2 component of the CCR4-NOT complex, harbors a N-terminal domain divergent from that of yNOT2 -required for transcriptional activation and interaction with the yeast ADA2 factor-, but has conserved the C-terminal domain which is absolutely required for the yCCR4-associated function of yNOT2 [ 19 20 ] . Therefore, it looks as if genes of the CCR4-NOT complex have undergone a "concerted" phylogenetic evolution, with the yeast genes encoding multifunctional proteins and the animal genes only encoding "specialized" proteins specific for the CCR4-NOT complex.
In yeast, yCCR4 is one of the components of the 1.0 MDa CCR4-NOT complex, which also includes yPOP2 and at least five yNOT proteins.
In this complex, yPOP2 independently binds to yCCR4 and to yNOT1.
The 1.0 MDa complex contains yCCR4, yPOP2 (also referred to as yCAF1) and at least five yNOT1-5 proteins [ 5 6 7 ] . In this complex, yPOP2 independently binds to yCCR4 and yNOT1, and is absolutely required for yCCR4 to associate with the 1.0 MDa complex [ 6 7 ] . In the 1.9 MDa complex, yCCR4 binds to proteins such as yDBF2, a cell-cycle regulated protein kinase [ 2 ] , yCAF4 and yCAF16, and is essential for the interaction of both yCAF4 and yCAF16 with ySRB9, a component of the RNA polII holoenzyme [ 8 ] . yCCR4 was also reported to be associated with Paf1, Cdc73, and Hpr1 in a RNA polII complex distinct from the SRBP-containing holoenzyme [ 9 ] . Accordingly, yCCR4 contains, in its central region, a leucine-rich repeat (LRR) domain [ 10 ] which was demonstrated to be necessary for yCCR4 binding to the yPOP2 [ 5 11 ] , yDBF2 [ 2 ] , yCAF4 and yCAF16 [ 8 ] components of the CCR4-NOT complex.
A previous report [ 19 ] identified the human orthologs of yPOP2 (hPOP2/CALIF) and yNOT1 (hNOT1), and showed that they have conserved their ability to bind to each other.
Loading...