Words similar to ypop

Example sentences for: ypop

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This region can, by itself, activate transcription when targeted to the DNA via a heterologous DNA-binding domain [ 5 ] . On the other hand, the LRR plus C-terminal region of yCCR4 cannot mediate transcription activation, but is involved in protein-protein interactions [ 5 ] . The yCCR4 LRR is necessary for the binding of several components of the CCR4-NOT complex, including yPOP2 -and mCAF1- [ 11 ] , yDBF2 [ 2 ] , yCAF4 and yCAF16 [ 8 ] , and deletion of the yCCR4 N-terminus does not impair these associations.
Consistently, the region encompassing the LRR and part of the C-terminus (residues 302-668) has been defined as the smallest region necessary and sufficient for the association of yCCR4 with yPOP2 [ 11 ] .
If neither interpretation can as yet be favoured, it is noteworthy that yCCR4 evolution parallels that of its partner in the CCR4-NOT complex, namely yPOP2.
Second, yCCR4 was shown to be a component, in association with yPOP2, of the major yeast cytoplasmic mRNA deadenylase complex, and to be required for efficient poly(A)-specific mRNA degradation [ 14 15 ] . yCCR4 might be a catalytic subunit of this complex, because of its nuclease-like domain.
A previous report [ 19 ] identified the human orthologs of yPOP2 (hPOP2/CALIF) and yNOT1 (hNOT1), and showed that they have conserved their ability to bind to each other.