Example sentences for: ypop

How can you use “ypop” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Firstly, we identified yCCR4 mammalian orthologs and demonstrated that the human member can interact with the human yPOP2 homologs.

  • Likewise, mCAF1, which has lost the N-terminal transactivation domain of yPOP2, binds to yCCR4 with a higher affinity than yPOP2 [ 11 ] .

  • Second, yCCR4 was shown to be a component, in association with yPOP2, of the major yeast cytoplasmic mRNA deadenylase complex, and to be required for efficient poly(A)-specific mRNA degradation [ 14 15 ] . yCCR4 might be a catalytic subunit of this complex, because of its nuclease-like domain.

  • Two homologs of yPOP2 have been identified in mammals: the mouse/human CAF1 [ 11 16 17 33 ] and, more recently, the human homolog named hPOP2 or hCALIF [ 18 19 ] . Both mCAF1 [ 11 ] and hPOP2 [ 19 ] interact with yCCR4, and the yCCR4 LRR is essential for these interactions.

  • To determine whether yCCR4-yPOP2 interactions are evolutionarily conserved, we examined whether hCCR4 can bind hCAF1 and hPOP2 in a two-hybrid assay in mammalian cells.


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