Example sentences for: ypop
How can you use “ypop” in a sentence? Here are some example sentences to help you improve your vocabulary:
To confirm these data and gain some hints for the existence of a CCR4-NOT complex in mammals, we investigated whether the interaction between yCCR4 and yPOP2 in the CCR4-NOT complex is conserved for the human ortholog, hCCR4.
Firstly, we identified yCCR4 mammalian orthologs and demonstrated that the human member can interact with the human yPOP2 homologs.
Consistently, the region encompassing the LRR and part of the C-terminus (residues 302-668) has been defined as the smallest region necessary and sufficient for the association of yCCR4 with yPOP2 [ 11 ] .
Here we report the identification of nineteen yCCR4-like proteins in eukaryotes and show, by phylogenetic and genomic analyses, that they are grouped into four distinct families, one of which contains the yCCR4 orthologs : these orthologs, in animals, have conserved the yCCR4 leucine-rich repeat, and we show, using two-hybrid assays and far-Western experiments, that the human protein binds to the human yPOP2 homologs, i.e. hCAF1 and hPOP2, in a LRR-dependent manner.
Likewise, mCAF1, which has lost the N-terminal transactivation domain of yPOP2, binds to yCCR4 with a higher affinity than yPOP2 [ 11 ] .