Words similar to upa
Example sentences for: upa
How can you use “upa” in a sentence? Here are some example sentences to help you improve your vocabulary:
This example illustrates how functional relationships that could not be deduced from gene names were uncovered through the analysis of patterns of term occurrence: matrix metalloproteinases (MMP1, 10, 14) and urokinase plasminogen activator (UPA, SPARC) are matrix-interacting molecules involved in tumor invasion and metastasis.
Fast TGFβ responder genes, such as smad7 , whose maximum activation by TGFβ was reached after 60 min, was only slightly affected by SB-203580, while slow responders, such as pai-1, pthrp or upa , that showed peak activation after 180-240 min, were very sensitive to the repressive effect of SB-203580.
The genes being examined were divided into two groups: I, known TGFβ target genes: pai-1, smad7, c-myc, upa and pthrp (Fig.
When excess equal amount of thrombin was incubated with equal amount of PAI-1s in term of inhibitory activity against uPA, mutant inhibitors were neutralized faster by thrombin than wtPAI-1, and vitronectin also facilitated the neutralization of Glu351Ala or Glu351Arg by thrombin, just similar to the wtPAI-1 (Fig.
The smad7 gene contains a perfect palindromic Smad binding element (GTCTAGAC) while the pai-1 and the pthrp promoters harbor AGAC tandem repeats [ 19 33 ] which binds Smad proteins less efficiently [ 34 ] . The upa gene contains only an AP1-binding site which resembles the Smad3/4-responsive AGAC motif [ 35 ] . A weaker binding site could require Smad3 to be present at higher concentrations for efficient binding and would make TGFβ-dependent transcription from a gene more vulnerable to reduced nuclear accumulation of the Smad3 protein.
Loading...