Example sentences for: upa

How can you use “upa” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This indicates that Glu351 is not essential for the interaction with tPA, but it is an very important determinant for the optimal interaction with uPA, thrombin and plasmin.

  • For example, positively charged amino acids in the variable region of tPA, uPA and thrombin play dominant roles in the specific interaction with PAI-1.

  • The smad7 gene contains a perfect palindromic Smad binding element (GTCTAGAC) while the pai-1 and the pthrp promoters harbor AGAC tandem repeats [ 19 33 ] which binds Smad proteins less efficiently [ 34 ] . The upa gene contains only an AP1-binding site which resembles the Smad3/4-responsive AGAC motif [ 35 ] . A weaker binding site could require Smad3 to be present at higher concentrations for efficient binding and would make TGFβ-dependent transcription from a gene more vulnerable to reduced nuclear accumulation of the Smad3 protein.

  • 1 μg/ml) was incubated at 37°C for 30 min with same amount of wtPAI-1, E351A and E351R in term of inhibitory activity toward uPA (20 U in the concentration range of 4-10 μg/ml) in absence or presence of vitronectin (60 μg/ml).

  • The inhibitory activities of wtPAI-1 and mutants were measured by a direct chromogenic assay using uPA (100 U/μg) and substrate S-2444.


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