Words similar to upa

Example sentences for: upa

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The specific inhibitory activities of wtPAI-1, Glu351Ala and Glu351Arg were assessed with uPA and S-2444.
One of great importance, urokinase (uPA) and its high affinity receptor, the GPI-anchored membrane CD87 (uPAR), is critical in tumour progression and its level of expression is correlated with poor prognosis of various cancers such as prostate [ 2 ] , breast [ 3 ] , colon [ 4 ] , ovarian [ 5 ] , gastric [ 6 ] , brain [ 7 ] , and lung cancer [ 8 ] . Urokinase (uPA) and its main product plasmin belong to the very early proteases [ 9 10 11 ] that activate the metallo-protease (MMP) cascade and therefore control cell motility, tissue remodelling and the activation of various angiogenic factors (VEGF, TGFβ).
uPA) are localised at the tumour site through receptors that are highly expressed on the surface of activated endothelial cells and tumour cells.
Fast TGFβ responder genes, such as smad7 , whose maximum activation by TGFβ was reached after 60 min, was only slightly affected by SB-203580, while slow responders, such as pai-1, pthrp or upa , that showed peak activation after 180-240 min, were very sensitive to the repressive effect of SB-203580.
The interaction of Glu351 with uPA is much more important than that of Glu351 with tPA, which is demonstrated by improved reactivity of Glu351 mutants toward uPA, but not toward tPA, showing that tPA is not directly interact with Glu351 of PAI-1, whereas Glu351 is necessary for the optimal interaction with uPA.