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Example sentences for: upar

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uPAR: Urokinase Receptor
A high level of uPAR at the invasive edge of the tumour concentrates uPA where neoangiogenesis occurs [ 12 ] , generating the full activation of the MMP cascade [ 13 ] . Furthermore, various cellular migrations proceed upon the transient attachment of the uPAR to matrix components (e.g.
The transmembranous urokinase-type plasminogen activator receptor (uPAR; CD87) focuses the formation of active plasmin at the cell surface, thus enhancing directional extracellular proteolysis.
The receptor of ATF-BPTI (uPAR) is known to be principally present at the outer edge of the tumour mass and as the volume increases, the proportion of uPAR in the tumour will decrease.
Systemic and local delivery of an adenovirus encoding ATF have been shown to inhibit the growth of primary tumour implants as well as of tumour metastasis in different animal models [ 18 19 ] . In the ATF-BPTI chimeric protein, ATF has two functions (1) the anti uPA effect with its known angiostatic activity and (2) delivery of BPTI at the tumour site due to over-expression of uPAR on tumour and endothelial cells.