Words similar to upar

Example sentences for: upar

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The transmembranous urokinase-type plasminogen activator receptor (uPAR; CD87) focuses the formation of active plasmin at the cell surface, thus enhancing directional extracellular proteolysis.
Systemic and local delivery of an adenovirus encoding ATF have been shown to inhibit the growth of primary tumour implants as well as of tumour metastasis in different animal models [ 18 19 ] . In the ATF-BPTI chimeric protein, ATF has two functions (1) the anti uPA effect with its known angiostatic activity and (2) delivery of BPTI at the tumour site due to over-expression of uPAR on tumour and endothelial cells.
In contrast, uPAR has been shown to regulate plasminogen-mediated extracellular proteolysis during angiogenesis [ 21 ] .
uPAR: Urokinase Receptor
A high level of uPAR at the invasive edge of the tumour concentrates uPA where neoangiogenesis occurs [ 12 ] , generating the full activation of the MMP cascade [ 13 ] . Furthermore, various cellular migrations proceed upon the transient attachment of the uPAR to matrix components (e.g.