Words similar to uorfs

Example sentences for: uorfs

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The uORFs are involved mechanistically in the enhanced initiation of these mRNAs [ 25 ] .
The uORFs are involved mechanistically in bringing about enhanced translation initiation under conditions that otherwise favor a general decrease in translation initiation [ 25 ] . Within the 5' UTR of countin mRNA, we find uORFs similar in number and in arrangement to those of GCN4 mRNA, the major mRNA regulated by yeast GCN2 [ 25 ] . Thus, we suggest that countin mRNA, and probably other as yet identified mRNAs, are translationally upregulated when IfkA phosphorylates eIF2α during the preaggregation period, or from 1 to 7 hours after the onset of development.
An examination of the 5' untranslated region (5'UTR) of the countin mRNA revealed 5 short upstream open reading frames (uORFs).
A hallmark of mRNAs, including the yeast GCN4 mRNA, that are specifically regulated by GCN2 of yeast and mammals is the presence of several uORFs within the 5' UTR [ 24 25 ] . The uORFs of countin mRNA, along with those of yeast GCN2 mRNA, are shown schematically in fig.