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Example sentences for: unstable

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Wortmannin is a fungal metabolite that is a relatively selective inhibitor of PI 3-kinase with a half-maximal inhibition (IC 50 ) less than 5 nM [ 11 ] . In the wortmannin experiments, media were changed every 2 hours for a total of 12 hours in all of the conditions because wortmannin is unstable in solution at physiological pH [ 19 ] . The shorter incubation time with insulin in the wortmannin experiments resulted in a decreased inhibitory effect of insulin, i.e., an ~22% inhibition of SP-A mRNA levels (Fig.
Together, these results suggest that PTGS in certain oligomeric T-DNA loci is unstable and has a tendency to progress to TGS.
There is currently only one ongoing randomized placebo-controlled trial of early versus delayed statin therapy in this setting, A-2-Z (Aggrastat to Zocor, Merck) [ 29 ] . The A-2-Z study is evaluating the efficacy of early treatment with simvastatin in 4,500 patients following an episode of unstable angina or a non-Q wave myocardial infarction.
Since truncated fragments may be unstable in yeast and may not accumulate to levels sufficient to produce a positive result, we used roughly equal amounts of each truncated protein to test for binding to TOP1 in nuclear extracts.
Earlier secondary prevention statin trials had excluded patients with unstable coronary syndromes largely out of theoretical concern that statin-mediated reductions in vascular smooth muscle cell proliferation might destabilize healing plaque.