Words similar to up-regulation

Example sentences for: up-regulation

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We then introduced into each line a plasmid containing a luciferase reporter downstream of multimerized Gli binding sites and a minimal promoter [ 20 ] . An isolated stable clone of the 10T1/2 cell transfectants (referred to as clone S12) gave a 10-20-fold up-regulation of luciferase activity (Figure 1a) when stimulated with Hh protein [ 21 ] for 24 hours.
The specificity of the signals driven by PMA was further stressed by the up-regulation of CD3 expression and by the unaltered mRNA levels of the proto-oncogene c-Ha-ras.
Contrary to these findings, other investigations have been unable to demonstrate any changes in sodium/glucose co-transport when examining brush border membrane vesicles [ 28 ] . The up-regulation of intestinal sodium-linked nutrient absorption by cftr may occur via a mechanism that does not involve changes of the brush border membrane but rather intracellular components [ 28 ] . Intestinal sodium-linked nutrient absorption would then be undetectable in brush border membrane vesicle studies.
In agreement with this possibility, transcripts encoding RPs L6 and S7 are reported to be up-regulated in regenerating liver [ 33 ] . However, for the study involving responses of neuroblastoma cells to N-Myc, despite the massive up-regulation of RP transcripts, there was no over-all increase in the rate of protein synthesis [ 18 ] .
This suggests that there may be a constant time of up-regulation of gene expression following fracture in the rat.