Words similar to up-regulation
Example sentences for: up-regulation
How can you use “up-regulation” in a sentence? Here are some example sentences to help you improve your vocabulary:
It has previously been shown that IL-8 mRNA induction was seen less then 1 h after Tat (72aa) stimulation, and levels remained elevated for up to 24 h, leading to IL-8 protein production [ 102 ] . Along these lines, we have previously shown that the IL-8 gene is expressed in a cell cycle-dependent manner in cells that express the Tat protein, and the induction is during the S phase of the cell cycle and regulated by stable NF-kB binding to the IL-8 promoter [ 103 ] . When looking for IL-8 at the G1/S border, we found that all Tat containing cells, including PBMCs that were treated with exogenous Tat showed an up-regulation of IL-8 in the supernatant (Figure 4), further implying that results obtained from the H9/Tat system may infact be of general physiological relevance in vivo.
We then introduced into each line a plasmid containing a luciferase reporter downstream of multimerized Gli binding sites and a minimal promoter [ 20 ] . An isolated stable clone of the 10T1/2 cell transfectants (referred to as clone S12) gave a 10-20-fold up-regulation of luciferase activity (Figure 1a) when stimulated with Hh protein [ 21 ] for 24 hours.
In this regard, SI, lactase, and the receptor for 1,25 OH-VitD3 (VDR) share transcriptional regulation through the homeodomain transcription factor CDX2 [ 33 34 ] . The possibility that SI or lactase deficiency could cause secondary up-regulation of VDR awaits exploration in cell culture or animal models.
Natural Killer (NK) cells are the main lymphocytic population constitutively expressing p75β chain of the IL-2 receptor and exhibiting up-regulation of LFA-1 (Lymphocyte Function associated Antigen-1) molecule upon IL-2 stimulation.
For immune and inflammatory response, the team identified many genes associated with aberrant immune response; it is not surprising, perhaps, to find a general up-regulation of immune response and antigen presentation in IBD.
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