Example sentences for: up-regulation

How can you use “up-regulation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Natural Killer (NK) cells are the main lymphocytic population constitutively expressing p75β chain of the IL-2 receptor and exhibiting up-regulation of LFA-1 (Lymphocyte Function associated Antigen-1) molecule upon IL-2 stimulation.

  • The results from this study demonstrate down regulation of cyclins, and up-regulation of cyclin inhibitor p21 and IL-10 mRNA expression.

  • For instance, viruses including Herpes simplex virus type 1 (HSV-1) have been known to induce severe alterations of the host translational apparatus, including the up-regulation of ribosomal proteins and the progressive association of several nonribosomal proteins, such as VP19C, VP26, and the poly(A)-binding protein 1 (PAB1P) to ribosomes [ 39 ] . In the case of HIV-1, approximately one infectious HIV-1 genome in an infected cell could be transcribed and translated into 50,000 to 100,000 physical particles [ 40 ] . This poses an immense challenge for the virus to be able to transcribe, splice, transport, and translate its RNA into fully packaged virions in a timely fashion.

  • The specificity of the signals driven by PMA was further stressed by the up-regulation of CD3 expression and by the unaltered mRNA levels of the proto-oncogene c-Ha-ras.

  • We had anticipated that the older rats would have an up-regulation of regulatory gene expression to attempt to accelerate the healing process.


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