Example sentences for: up-regulation

How can you use “up-regulation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We found an up-regulation of NKG2C with a balanced differential expression of 5.8 in cDNA microarray (Fig.

  • Natural Killer (NK) cells are the main lymphocytic population constitutively expressing p75β chain of the IL-2 receptor and exhibiting up-regulation of LFA-1 (Lymphocyte Function associated Antigen-1) molecule upon IL-2 stimulation.

  • Given the suggestion that an up-regulation of c-jun is a cause of PCD [ 15 16 ] , a reduction in c-jun activation by PPAR agonists should attenuate 25-OH-cholesterol induced cytotoxicity.

  • Triggering of the UPR also results in the suppression of global protein synthesis, as PERK is activated and phosphorylates EIK2α, which can only interact with the appropriate ribosomal binding sites in an unphosphorylated state [ 11 12 ] . While the upregulated transcription of PERK is not required for its activation, it's over expression can lead to the enhanced phosphorylation (and therefore inactivity) of EIK2α [ 16 ] . Therefore, its up-regulation by mefloquine supports the hypothesis that the drug triggers an UPR.

  • Treatment with RU486 resulted in apparent pituitary ACTH up-regulation as evidenced by increased immunolabeling regardless of genotype (Figure 4Cand 4D).


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