Example sentences for: up-regulation

How can you use “up-regulation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The following results of this study suggest that HIV-1 expression leads to cyclin D 1 -mediated G 1 → S progression in infected podocytes: cyclin D 1 transcript and protein levels are markedly up-regulated, phospho-Rb (Ser780) levels are increased, cyclin D 1 protein and phospho-Rb (Ser780) levels do not decrease with podocyte cell-cell contact and differentiation, and the up-regulation of cyclin D 1 requires the expression of HIV-1 genes, particularly HIV-1 nef.

  • In this regard, SI, lactase, and the receptor for 1,25 OH-VitD3 (VDR) share transcriptional regulation through the homeodomain transcription factor CDX2 [ 33 34 ] . The possibility that SI or lactase deficiency could cause secondary up-regulation of VDR awaits exploration in cell culture or animal models.

  • Fracture is followed by four weeks of up-regulation of the stimulatory cytokines after fracture, and healing must take place within that window of time if it is to occur.

  • We had anticipated that the older rats would have an up-regulation of regulatory gene expression to attempt to accelerate the healing process.

  • In contrast, cell-cell contact in wild-type and control-infected, but not HIV-1-infected podocytes, caused a severe down-regulation of cyclin D 1 transcript and protein concomitant with the up-regulation of synaptopodin, a podocyte differentiation marker [ 7 28 ] , by the end of the 14-day differentiation period.


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