Example sentences for: up-regulating

How can you use “up-regulating” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Interestingly, inhibition of Rho-p160ROCK has recently been shown to give similar lymphocyte morphology as inhibition of Rho with C3 [ 50 ] . Another interesting candidate may be p120 PKN, as recent studies have established that PKN phosphorylates cytoskeletal intermediate filaments [ 47 ] and is directly linked to the cytoskeletal network through associations with α-actinin [ 48 ] . Also, PKN may be involved in relating cytoplasmic signals to the nucleus, for in response to stress, nuclear translocation of PKN occurs [ 49 ] . This is particularly important in light of previous work demonstrating that inactivation of Rho in peripheral blood T lymphocytes inhibits costimulatory signals up-regulating IL-2 production [ 25 ] . Future experiments will focus on determining the relationship of Rho GTPases and the regulation of T cell morphology [ 25 51 52 ] .

  • Secondly, we utilized single gene mutants of HIV-1 [ 8 ] to determine which HIV-1 gene(s) may be involved with up-regulating cyclin D 1 expression.

  • It has been reported that dysfunction of the p53/MDM-2 pathway can be found in more than two-thirds of angiosarcomas; thus, mutant p53 influences the development of angiosarcoma not only by affecting growth and apoptosis control but also by up-regulating VEGF (Chinrugi et al.


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