Words similar to up-regulate
Example sentences for: up-regulate
How can you use “up-regulate” in a sentence? Here are some example sentences to help you improve your vocabulary:
Cumulatively, however, these observations do suggest a mechanism whereby HIV-1 expression in renal epithelium may induce cyclin D 1 : activation of Src-family kinases by Nef would be expected to up-regulate cyclin D 1 gene expression and promote the synthesis and stabilization of cyclin D 1 protein via Src-Ras-MAPK and Src-PI3K-mTOR signal transduction pathways, respectively [ 32 33 34 ] . Interestingly, our unpublished in vitro observations and published data showing marked expression of basic fibroblast growth factor in the interstitium of HIVAN kidneys [ 35 ] suggest that soluble mitogens may be important cofactors with HIV-1 expression to induce cyclin D 1 . Thus, interrupting HIV-1 gene expression should down-regulate cyclin D 1 and correct the phenotypic abnormalities in infected podocytes.
Homogenates of lungs from non-infected and P. carinii -infected rats were used to inoculate a human cell line, the HEL cell line, to determine whether P. carinii would up-regulate or induce gene expression in infected HEL cells.
In primary cultures of choroid plexus cells, repeated 5-HT application desensitizes 5-HT induced increases in intracellular calcium [ 13 ] . Down-regulation of receptor binding sites in choroid plexus cells is seen after agonist treatment [ 29 ] . However, inverse agonists can either down- [ 29 ] or up-regulate [ 30 ] 5-HT 2C receptor binding sites dependent upon cellular context.
Second C57mg cells co-cultured with Wnt-5a secreting cells up-regulate SL-1.
Tissue hypoxia therefore remains a possible mechanism of increased expression of Fas and FasL, although it seems less likely that the arteriolosclerosis that developed in S kidneys was severe enough to produce hypoxic conditions sufficient to up-regulate Fas, until the third week of study.
Loading...