Words similar to up-regulated
Example sentences for: up-regulated
How can you use “up-regulated” in a sentence? Here are some example sentences to help you improve your vocabulary:
To further examine how SL-1 is up-regulated by Wnt-5a, we tested whether SL-1 induction could be mediated by downstream effectors of Wnt/Ca 2+signaling such as PKC.
Caspase 6 is activated by active Caspase 3 and in turn cleaves lamin, resulting in nuclear membrane fragmentation [ 55 ] . FAF interacts with the cytoplasmic domain of the Fas receptor to potentiate Fas-mediated apoptosis [ 56 57 ] . Thus, the up-regulated cell cycle inhibitors and apoptotic proteins clearly favor cell cycle arrest and death.
Measurements of mRNA and protein made in many laboratories using diverse methodologies have identified approximately 40 genes that are up-regulated and 25 down-regulated after peripheral nerve injury [ 3 5 6 ] . These regulated genes include members of several classes: G protein coupled receptors, ligand- and voltage-gated ion channels, receptor tyrosine kinases, growth factors, cytokines, neuropeptides, cell cytoskeletal genes, cell surface/extracellular matrix genes, and a miscellaneous group of enzymes.
Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are nuclear transcription factors that mediate the action of retinoids [ 11 12 ] . We have demonstrated that in the rat, castration resulted in an increase in mRNAs for RAR α and γ in the prostate; such effects were prevented by T replacement [ 13 ] . We also demonstrated that the levels of mRNAs for RAR α and γ in non-tumorigenic rat epithelial cells (NRP152) were down-regulated, whereas those in tumorigenic cells (NRP154) were unaffected or up-regulated following T treatment [ 14 ] . In addition, RAR α was over-expressed in tumorigenic NRP154 cells.
Numerous transcripts were up-regulated in conceptuses of filamentous morphology including, pro-interleukin-1β, interleukin-1β (IL-1β), s-adenosylhomocysteine hydrolase (SAHH), heat shock cognate 70 kDa protein (HSC70), metallopanstimulin-1 (MPS-1) and elfin.
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