Example sentences for: up-regulated

How can you use “up-regulated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Cytokeratin 14 expression is associated with proliferative epidermal keratinocytes at wound sites [ 24 ] . Such expression in control unwounded skin (0 day) is, as expected, very low but increased appreciably by day 2 after wounding with peak expression at day 4. Interestingly, expression of cytokeratin 14 was up-regulated in the normal epidermis and neoepidermis of SPARC-null mice relative to those of wild-type mice (Fig.

  • Results in Table 1indicate that although few receptor genes were up-regulated, most of the cellular receptors in general, were down-regulated in the presence of the Tat protein.

  • While lysozyme, PACAP, MET-1 are all up-regulated, for MET1 this is only transient.

  • For example, RP L18, which was significantly down-regulated by NGF, has been reported to negatively regulate double-stranded RNA (dsRNA)-activated protein kinase (PKR) [ 45 ] . As an additional example RP S19, which is also down-regulated by NGF, has been implicated in erythropoiesis and has also been described as a monocyte chemotactic factor [ 46 ] . As one last example, rat RP L9 which we found to be up-regulated by NGF starting within a few hours and maximally by 8 hrs, has been shown to be the ortholog of the yeast gene grc5 which appears to be involved in multiple cellular functions including growth control, cytoskeleton control and energy metabolism [ 47 ] . Identification of NGF-regulated RPs should now facilitate exploration of their potential roles in the responses of cells to neurotrophins.

  • For example, genes for human autoantigen and human carboxyl ester lipase-like protein would be considered up-regulated in the microarray (according to PM match hybridization) if the MM hybridization values were ignored in the fold change calculation.


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