Example sentences for: up-regulated

How can you use “up-regulated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The following results of this study suggest that HIV-1 expression leads to cyclin D 1 -mediated G 1 → S progression in infected podocytes: cyclin D 1 transcript and protein levels are markedly up-regulated, phospho-Rb (Ser780) levels are increased, cyclin D 1 protein and phospho-Rb (Ser780) levels do not decrease with podocyte cell-cell contact and differentiation, and the up-regulation of cyclin D 1 requires the expression of HIV-1 genes, particularly HIV-1 nef.

  • Among the adhesion molecules up-regulated in IBD, MAdCAM-1, the mucosal cell adhesion molecule, is thought to be preeminent in the development of chronic gut inflammation.

  • However, with ADGE microarray, there were 63 genes >4 fold up-regulated, 220 genes 2-4 fold up-regulated, 92 genes 2-4 fold down-regulated and 14 genes >4 down-regulated.

  • Genes associated with the cell cytoskeleton, positive and negative regulators of apoptosis as well as immune markers tend to be up-regulated, whereas genes involved in membrane excitability (ion channels) or neurotransmission (neurotransmitters and vesicle trafficking genes) tend to be down-regulated.

  • It is interesting to note that Cdc2 (Acc# X05360), Cdc10 homolog (Acc# S72008), and Cdc37 (Acc# U43077) were all up-regulated in Tat expressing cells.


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