Words similar to ubiquitination
Example sentences for: ubiquitination
How can you use “ubiquitination” in a sentence? Here are some example sentences to help you improve your vocabulary:
As an initial step to study a possible role of mammalian COP1 in ubiquitination, we transiently expressed FLAG-tagged COP1 (FLAG-COP1) in human cell line 293 together with HA-tagged ubiquitin (HA-Ub), followed by immunoprecipitation with anti-FLAG antibodies.
Thus, COP1 RING finger could also play dual roles in ubiquitination as well as nuclear import.
In addition to the key roles in E3 ligase activity, RING finger domains have also been shown to be important for regulating subcellular localization of E3s and/or their substrates in a number of cases [ 53 54 55 56 ] . Studies have shown the MDM2 RING finger domain is required to promote nuclear export of p53 and this activity of MDM2 RING finger seems to be coupled with its ability to promote ubiquitination of p53 [ 53 54 55 ] . Rbx1/ROC1, the small RING finger subunit of the SCF E3 complexes, promotes the nuclear accumulation of Cul1, another subunit of the SCF complexes [ 56 ] . These studies have suggested a correlation between the ubiquitination activities of RING fingers and their roles in regulating subcellular localization of the E3 ligases which they are part of.
Because of its role in mediating the degradation of HY5, HYH, and possibly other transcription factors in Arabidopsis [ 4 5 ] and the presence of a RING finger domain and a WD-40 domain, AtCOP1 has been proposed to function as a RING-finger type ubiquitination E3 ligase, by recruiting E2 through its RING-finger domain and binding to the substrates through the WD-40 repeats [ 4 43 ] . This hypothesis is also supported by the findings about other negative regulators of plant photomorphogenesis.
Although this model implies that the misfolded poly-Gln protein might be the primary substrate for ubiquitination, a recent study by Suhr et al . [ 60 ] suggests that this may not always be the case.
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