Words similar to ubiquitination

Example sentences for: ubiquitination

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Evidence for a role of COP1 in protein ubiquitination in vivo
A variety of autoantigens are cleaved into signature fragments during apoptosis and necrosis [ 20 ] . Other cell death post-translational modifications in autoantigens include hyperphosphorylation, (de)ubiquitination, methylation, citrullination, and transglutaminase crosslinking [ 21 22 ] .
This RING-fmger domain has been shown to be necessary for the ubiquitination function of Siah1a [ 46 ] . As a positive control for expression, this construct was fused to the C-terminus of GFP (figure 5A).
This leads to Cdc34-dependent ubiquitination and degradation of Sic1.
In addition to the key roles in E3 ligase activity, RING finger domains have also been shown to be important for regulating subcellular localization of E3s and/or their substrates in a number of cases [ 53 54 55 56 ] . Studies have shown the MDM2 RING finger domain is required to promote nuclear export of p53 and this activity of MDM2 RING finger seems to be coupled with its ability to promote ubiquitination of p53 [ 53 54 55 ] . Rbx1/ROC1, the small RING finger subunit of the SCF E3 complexes, promotes the nuclear accumulation of Cul1, another subunit of the SCF complexes [ 56 ] . These studies have suggested a correlation between the ubiquitination activities of RING fingers and their roles in regulating subcellular localization of the E3 ligases which they are part of.