Example sentences for: ubiquitination

How can you use “ubiquitination” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • TOP1 has been shown to interact with many proteins including components of the holo TFIIIC complex [ 1 ] , TFIID [ 2 ] , p53 [ 3 ] , SV-40 large T antigen [ 4 ] , nucleolin [ 5 ] , the RING finger protein topors [ 6 ] , the RNA splicing factors PSF/p54 nrb [ 7 ] and SF2/ASF [ 8 ] , the cell cycle regulatory protein ARF [ 9 ] , RNA pol II complex [ 10 11 ] , and HTLV type 1 tax oncoprotein [ 12 ] . TOP1 also interacts with a variety of unidentified proteins involved in its phosphorylation, ubiquitination and sumoylation [ 13 14 15 16 17 ] .

  • To further investigate whether COP1 itself undergoes ubiquitination, a His-tagged ubiquitin expression construct (His-Ub) was co-transfected into the 293 cells with FLAG-COP1, followed by His purification under denaturing condition (in 8 M Urea).

  • Although this model implies that the misfolded poly-Gln protein might be the primary substrate for ubiquitination, a recent study by Suhr et al . [ 60 ] suggests that this may not always be the case.

  • While SCF triggers ubiquitination and proteasome action degrades many substrates to completion, a few targets are instead cleaved and partially degraded.

  • Interestingly, ubiquitination is a reversible process.


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