Words similar to ubiquitination
Example sentences for: ubiquitination
How can you use “ubiquitination” in a sentence? Here are some example sentences to help you improve your vocabulary:
CRY poteins may play a role at steady state levels or there may be post-translational changes in the functioning of CRY proteins in association with sleep deprivation, such as phosphorylation state, ubiquitination [ 38 ] , or intracellular localization [ 46 ] of the protein, all of which are regulated dynamically, at least in vitro . In the liver, CRY protein oscillations are not necessary for circadian oscillations of target transcripts, as CRY proteins are present in excess of PER and oscillations in the latter produce rhythmicity [ 46 ] . A similar situation might exist in the cortex.
Our results suggest that mammalian COP1 might play a role in ubiquitination (Fig 2).
A number of RING finger proteins have recently been shown to act as E3 ubiquitin ligases [ 24 ] . WD40 domains have also been frequently found in E3 complexes as substrate recruiting domains [ 25 26 27 28 ] . Despite compelling evidence from Arabidopsis implying that COP1 may mediate protein degradation [ 4 5 ] , no direct evidence of COP1 participating in ubiquitination has been reported.
This leads to Cdc34-dependent ubiquitination and degradation of Sic1.
Indeed, a similar explanation has been invoked to explain the presence of Hsp70 and ubiquitin in nuclear aggregates observed in cells expressing abnormal gene products with poly-Gln tracts, such as huntingtin [ 54 ] and ataxin-1 [ 59 ] . Based on reports that overexpression of chaperones [ 59 62 ] or a dominant-negative form of the ubiquitin-conjugating enzyme [ 63 ] can suppress the formation of poly-Gln protein aggregates, Kaytor and Warren [ 58 ] proposed a three-stage model wherein (i) molecular chaperones initially associate with the misfolded protein, (ii) failure to diminish the pool of misfolded protein leads to aggregation and ubiquitination and (iii) inefficient degradation of the aggregate by the proteasome is manifested by the accumulation of inclusion bodies.
Loading...