Words similar to ubiquitin
Example sentences for: ubiquitin
How can you use “ubiquitin” in a sentence? Here are some example sentences to help you improve your vocabulary:
An immunofluorescence study was performed to determine whether or not the intranuclear Rab24(D123I) aggregates might sequester ubiquitin and Hsp70.
The Seven in Absentia (SinA) protein was discovered in Drosophila as a mediator of photoreceptor development [ 29 ] . Subsequently, SinA was shown to participate in the ubiquitin/proteasome pathway [ 30 31 ] . The presence of a RING finger domain in the N-terminus of the mammalian homologue of SinA, "Siah", suggests it may be involved in targeting specific proteins for degradation in the proteasome as a ubiquitin ligase [ 32 ] . Two mammalian genes encoding Siah, Siah1 and 2, are known.
Now that it is evident that the proteasome contains a member of a novel metalloprotease family, a fundamental question can be raised: why does a proteolytic enzyme like the proteasome need auxiliary proteases for hydrolysis of ubiquitin domains?
Thus, CSN deficiency appears to stimulate Pcu3p-associated ubiquitin ligase activity in vitro . A similar stimulation was obtained for substrate-specific polyubiquitylation of phosphorylated Rum1p by SCF Poppurified from csn5 mutants (unpublished observation).
Indeed, a similar explanation has been invoked to explain the presence of Hsp70 and ubiquitin in nuclear aggregates observed in cells expressing abnormal gene products with poly-Gln tracts, such as huntingtin [ 54 ] and ataxin-1 [ 59 ] . Based on reports that overexpression of chaperones [ 59 62 ] or a dominant-negative form of the ubiquitin-conjugating enzyme [ 63 ] can suppress the formation of poly-Gln protein aggregates, Kaytor and Warren [ 58 ] proposed a three-stage model wherein (i) molecular chaperones initially associate with the misfolded protein, (ii) failure to diminish the pool of misfolded protein leads to aggregation and ubiquitination and (iii) inefficient degradation of the aggregate by the proteasome is manifested by the accumulation of inclusion bodies.
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