Words similar to ubiquitylation

Example sentences for: ubiquitylation

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The protein product of the mdm2 oncogene is over-expressed in a considerable number of tumors [ 27 ] . This protein is a pivotal negative regulator of p53 [ 27 ] ; it interacts with the P53 protein masking its transcriptional domain and accelerating its proteasomal degradation [ 21 27 ] . The later process involves the deacetylation and ubiquitylation of the p53 protein by mdm2 [ 28 ] . Inactivation and/or degradation of p53 diminishes the cell ability to undergo apoptosis [ 21 ] . Conversely, p53 may influence mdm2.
Our data suggest that androgen-mediated SKP2 downregulation is responsible for decreased ubiquitylation and accumulation of p27 in LNCaP cells, an effect that is readily overcome by overexpression of SKP2.
Moreover, Rum1p ubiquitylation was not obtained with Pip1p complexes prepared from cell lysate of pop2 deletion strains, proving the F-box protein dependency of this reaction (Fig.
Pop1p and Pop2p complexes were immunopurified with Myc antibodies and employed in in vitro ubiquitylation assays upon addition of E1, UBC3, ubiquitin, and ATP.
SKP overexpression for 24 or 48 h dramatically increased p27 ubiquitylation activity present in these cell lysates (Fig.