Example sentences for: ubiquitinated

How can you use “ubiquitinated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In addition, Skp2 knock-out cells do not accumulate E2F [ 21 ] and an E2F mutant unable to bind Skp2 is still ubiquitinated and unstable [ 21 ] . Thus, the basis of S phase destruction of E2F-1 remains unresolved.

  • The best-characterized example of ubiquitin-independent degradation is the degradation of ornithine decarboxylase (ODC), which is dependent upon ODC interaction with the targeting protein antizyme (Az) [ 18 ] . How ubiquitinated substrates or Az-bound ODC is recognized by the 26S proteasome is not well understood.

  • Immunoblot analysis of the immunoprecipitates with anti-HA antibodies detected multiple distinct bands and smear only when FLAG-COP1 and HA-Ub were co-expressed, indicating that at least a subset of COP1 associated proteins are ubiquitinated in human cells (Fig.

  • Therefore, mammalian COP1 not only associates with ubiquitinated proteins in vivo, but also itself a substrate for multi-ubiquitination.

  • Moreover, immunoblot analysis of the His 6 Rab24(D123I) isolated from cells treated with lactacystin (to block degradation of poly-ubiquitinated proteins by the 26S proteasome) showed no detectable ubiquitin associated with the protein, although the same antibody detected multiple ubiquitinated polypeptides in the whole-cell lysate (Fig.


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