Words similar to topologically

Example sentences for: topologically

How can you use “topologically” in a sentence? Here are some example sentences to help you improve your vocabulary:

Recently a new method for SNP detection from genomic DNA based on DNA ligase-mediated single nucleotide discrimination and signal amplification by Rolling Circle Amplification (RCA) has been described [ 6 7 8 9 10 ] . An oligonucleotide Open Circle Probe (OCP) anneals to the target SNP such that the 5' and 3' ends of the OCP can be ligated together forming a circle topologically linked to the target.
The yeast triphosphatase has a novel tertiary structure in which the active site is situated within a topologically closed hydrophilic tunnel composed of 8 antiparallel β strands, which are conserved in CaCet1 and Pct1 [ 2 ] . Mutational analysis of Cet1 has identified 15 individual side chains within the tunnel that are important for Cet1 function in vitro and in vivo [ 7 8 9 ] . Each of the 8 strands contributes at least one functional group to the active site.
Allele discrimination achieved at the ligation step results in small circular DNA molecules topologically linked to the target DNA strand.
Data on various single and compound neurotrophin null mutants have shown that the loss of a specific neurotrophin leads to topologically restricted loss of sensory neurons in the embryonic ear [ 4 5 ] . Such selective loss in Brn3c null mutants would therefore indicate reduction of a specific neurotrophin in immature hair cells.