Words similar to topologically

Example sentences for: topologically

How can you use “topologically” in a sentence? Here are some example sentences to help you improve your vocabulary:

Recently a new method for SNP detection from genomic DNA based on DNA ligase-mediated single nucleotide discrimination and signal amplification by Rolling Circle Amplification (RCA) has been described [ 6 7 8 9 10 ] . An oligonucleotide Open Circle Probe (OCP) anneals to the target SNP such that the 5' and 3' ends of the OCP can be ligated together forming a circle topologically linked to the target.
The yeast triphosphatase has a novel tertiary structure in which the active site is situated within a topologically closed hydrophilic tunnel composed of 8 antiparallel β strands, which are conserved in CaCet1 and Pct1 [ 2 ] . Mutational analysis of Cet1 has identified 15 individual side chains within the tunnel that are important for Cet1 function in vitro and in vivo [ 7 8 9 ] . Each of the 8 strands contributes at least one functional group to the active site.
Data on various single and compound neurotrophin null mutants have shown that the loss of a specific neurotrophin leads to topologically restricted loss of sensory neurons in the embryonic ear [ 4 5 ] . Such selective loss in Brn3c null mutants would therefore indicate reduction of a specific neurotrophin in immature hair cells.
Allele discrimination achieved at the ligation step results in small circular DNA molecules topologically linked to the target DNA strand.