Words similar to topoisomerase

Example sentences for: topoisomerase

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DNA topoisomerase I (TOP1) is a ubiquitously expressed protein that relaxes DNA supercoils generated during many transactions of DNA including replication, transcription, repair, and chromatin condensation and remodeling.
It has been suggested that the mechanisms of these two enzymes may be different [ 33 ] . Direct interaction between the enzyme and the passing strand may not be necessary for the T. maritima topoisomerase I activity.
Maximal yield of cleavage products was obtained for both Top67 and topoisomerase I within seconds after mixing of the enzyme and DNA so any potential difference in cleavage rates between the Top67 and topoisomerase I is unlikely to account for the difference in relaxation efficiency.
High concentration of DNA substrate is required to favor formation of catenanes catalyzed by topoisomerase I, and the enzyme also has to be present in higher concentration compared to the relaxation reaction.
Similarly, induction of apoptosis with 5 μM CPT, a topoisomerase I inhibitor [ 19 ] , led to a release of annexin V-binding MP which was prevented by ZVAD.