Words similar to topoisomerase

Example sentences for: topoisomerase

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We used CPT, an inhibitor of topoisomerase I, that is a well defined apoptogenic agent belonging to a promising class of antineoplastic drugs [ 23 ] . In contrast to more physiological stimuli (i.e, oxidative stress) induction of apoptosis by CPT is less complex and thus is a better model for study of MP-release phenomenon.
Previous studies have shown that E. coli DNA topoisomerase I cleavage of single-stranded DNA occurs with selectivity for sites with the C nucleotide base at the - 4 position [ 9 10 ] and that the enzyme preferentially cleaves at junctions of double-stranded and single-stranded DNA [ 8 ] . Several different 5'-end labeled substrates were prepared and used in cleavage assays to compare the cleavage sites selected by Top67 versus topoisomerase I. The results showed that with single-stranded substrates, Top67 also preferred cleavage sites with a C nucleotide base at the -4 position as reported for most of the type IA topoisomerases [ 12 ] . There were some differences from topoisomerase I in the relative distribution of cleavage products among the potential cleavage sites (Figure 4a,4b).
Finally, the in vivo catalytic activities of eukarytotic type IA topoisomerases, the topoisomerase III from various higher organisms may be related to their sequences.
We further focused our study on MP-release from HUVEC after proapoptotic stimulation with the topoisomerase I inhibitor camptothecin (CPT).
Top67 can recognize cleavage sites preferred by E. coliDNA topoisomerase I