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Example sentences for: til-
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Thus, to compare the effects of rIL-1Ra and tIL-1Ra producing cells under more dynamic conditions, perhaps closer to those that might be encountered in the joint in vivo , experiments were performed identically to that described for Fig 3except that one half of the culture media was replaced every 24 hours for 4 days.
Thus, under these conditions there were no dramatic differences between a single dose of rIL-1Ra and the tIL-1Ra producing cells.
For complete inhibition approximately 950 ng/ml rIL-Ra was required, whereas for the tIL-1Ra between 400 and 700 ng/ml was necessary.
2, however, a modest increase in the effectiveness of tIL-1Ra is suggested when one considers the relative concentrations of recombinant and transgenic IL-1Ra with time.
To allow sufficient time for the IL-1Ra producing cells to adhere and begin transgenic expression, we performed experiments similar to that above, but added the IL-1β 24 hours after addition of the range of doses of rIL-1Ra or tIL-1Ra producing cells to the HSF cultures.