Words similar to tbid

Example sentences for: tbid

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Although this mutant translocates to mitochondria as efficiently as does the WT with diminished disruptive effect on the outer membrane, it seems conceivable that tBid harbors two distinct signals, one for translocation to mitochondria, and the other for interaction with proteins or lipids to exert its pro-apoptotic function.
Mitochondria were washed 4 x 4 min in working buffer and incubated with the indicated anti-mouse secondary antibody conjugated to 10-nm (used for wild-type tBid) or to 5-nm (used for tBid G94E ) gold beads (1:50 Amersham) for 1 hr on ice in working buffer.
tBid - Truncated Bid, the C-terminal portion of Bid after cleavage by caspase-8.
1and 2) and was shown to destabilize lipid membranes in vitro (along with Bax) by increasing the permeabilization of artificial liposomes [ 25 26 ] . Therefore it is possible that tBid can bind to the cardiolipin rich contact site membranes and destabilize them by inducing Bax or Bak to oligomerize.
Indeed it was found that the targeting of tBid to mitochondria-like membranes occurs in the absence of proteins, yet depends upon cardiolipin being in a possibly unique structure as opposed to free cardiolipin [ 9 ] . The requirement for a specific cardiolipin structure that is likely defined by the contact site is consistent with our observation that no gold particles were found in regions stripped of the outer membrane exposing the cardiolipin-rich inner membrane.