Example sentences for: tgfβ-induced

How can you use “tgfβ-induced” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Next, we studied the time-course of TGFβ-induced Smad3 nuclear entry in the presence or absence of SB-203580.

  • However, both agents failed to reproduce the effect of the SB inhibitors as TGFβ-induced nuclear accumulation of Smad3 was not affected by these inhibitors (Fig.

  • It has recently been shown that SB-202190 and SB-203580 are able to inhibit TGFβ-induced phosphorylation of Smad3 by the TGFβ-receptor I kinase (ALK5) and to interfere with nuclear localization of Smad3 [ 17 ] . Nuclear translocation of Smad3 results directly from TGFβ-induced Smad3 phosphorylation and is, therefore, a measure of the activation status of ALK5.

  • The delayed TGFβ-mediated entry of Smad3 into the nucleus in the presence of SB-203580 prompted us to examine the effect of SB-203580 on TGFβ-induced gene expression in a time-course experiment.

  • We demonstrate that treatment of invasive MDA-MB-231 breast cancer cells with SB-202190 and SB-203580 interferes with TGFβ-induced Smad3 nuclear accumulation and that this is paralleled by a differential transcriptional response of TGFβ target genes.


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