Words similar to tgfβ-responsive

Example sentences for: tgfβ-responsive

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It is remarkable that a constitutively active form of JNK activator MKK and Smad7 are able to cooperatively downregulate TGFβ-responsive promoters [ 53 ] . It is quite possible that a Smad7/JNK synergistic interaction is involved in the TGFβ-dependent downregulation of Ese-1/Esx expression, where JNK alone might mediate the initiation of the TGFβ-induced repression.
Analysis of the human ets-1 promoter sequence revealed that it contains elements similar to TGFβ-responsive sites in other promoters (R.
SB-202190 and SB-203580 downregulate transcription from TGFβ-responsive genes
TGFβ has been shown also to stabilize the mRNA of the smad7 gene [ 25 ] , while stabilization of RNA does not play a major role in regulation of the pthrp gene in MDA-MB-231 cells [ 19 ] . In addition, SB-203580 also inhibits p38 activity which has been shown to play a role in TGFβ signalling [ 36 37 38 39 40 41 ] . Hence, several factors could be responsible for the differential sensitivity of TGFβ-responsive genes to SB-203580.
We have not analyzed the expression of this protein, since it preferentially inhibit bone morphogenetic protein (BMP)-induced expression [ 26 ] . In addition, Smad6 shows varying effects on TGFβ signalling [ 27 ] . Nor were TGFβ-responsive genes, such as p21, studied that are involved in cell cycle regulation.