Words similar to tgfβ-dependent
Example sentences for: tgfβ-dependent
How can you use “tgfβ-dependent” in a sentence? Here are some example sentences to help you improve your vocabulary:
The strongest effect of SB-203580 was found on the TGFβ-dependent expression of pthrp and upa . In these cases, the inhibitor completely eliminated responsiveness to TGFβ.
One way by which Smad7 can inhibit TGFβ-dependent gene expression is by blocking phosphorylation, and, hence, nuclear import of Smad3 and Smad2 [ 23 ] . More recent data showing that Smad7 is able to interact with histone deacetylases suggest an additional role for Smad7 as a transcriptional co-repressor [ 50 ] . Thus, Smad7 might interfere directly with Ese-1/Esx gene transcription.
Ese-1/Esx is a member of the Ets transcription factor family and is expressed mainly in epithelial tissue [ 30 ] . Its expression has been detected during mammary gland development and breast tumorigenesis [ 47 48 ] . It is noteworthy that Ese-1/Esx is a potential transcriptional regulator of the TGFβ type II receptor [ 31 ] and overexpression of Ese-1/Esx in non-invasive cells leads to a reduction in cell growth in the presence of TGFβ, presumably because of an increased TGFβ type II receptor level [ 49 ] . It is interesting that TGFβ-dependent downregulation of Ese-1/Esx is not affected by SB-203580.
Strikingly, SB-202190 and SB-203580 suppressed TGFβ-dependent activation of those genes that are important for the acquisition of invasive behavior, while having no effect on the expression of the natural TGFβ inhibitor Smad7.
It is remarkable that a constitutively active form of JNK activator MKK and Smad7 are able to cooperatively downregulate TGFβ-responsive promoters [ 53 ] . It is quite possible that a Smad7/JNK synergistic interaction is involved in the TGFβ-dependent downregulation of Ese-1/Esx expression, where JNK alone might mediate the initiation of the TGFβ-induced repression.
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