Example sentences for: tgfβ-rii

How can you use “tgfβ-rii” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In part the cells were preincubated with α V - and β 6 -antibodies (1:100 each for 30 min), with a TGFβ-RII antibody (15 μg/ml for 30 min), cytochalasin D, BAPTA AM and MEK1 inhibitor PD98059, respectively.

  • In part the cells were preincubated with α V - and β 6 -antibodies (1:100 each for 30 min), with a TGFβ-RII antibody (15 μg/ml for 30 min), cytochalasin D and BAPTA AM, respectively.

  • Preincubation with a TGFβ-RII blocking antibody attenuated the TGFβ 1 induced pattern, contrary to SMAD 4 deleted BxPC-3 cells.

  • This finding is supported by the observation that activation of p21/Ras and MAPK ERK1/2 induced by TGFβ 1 is only reverted to the control level by the combination of the TGFβ-RII blocking antibody and the α V β 6 -blocking antibodies, or by inhibition of MEK1.

  • Linking of the TGFβ-R pathway to the Ras/MAPK pathway is dependent on a functional SMAD4 gene product, because TGFβ 1 induced gene expression and activation of Ras and ERK1/2 is attenuated by the TGFβ-RII blocking antibody only in SMAD4 wild type cells, whereas in the SMAD4 deleted BxPC-3 cells, no such influence was observable.


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