Words similar to tetraspanins

Example sentences for: tetraspanins

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The tetraspanins are a family of cell-surface proteins with four transmembrane domains, two extracellular loops, and conserved cysteine residues at key positions in the second extracellular loop [ 1 ] . They facilitate a wide array of functions, including cell activation, differentiation, adhesion, morphological changes, and motility, which may all relate to the promiscuous associations of these molecules with integrins and other signaling proteins within the cell membrane and the cytoskeleton.
CD81, a defining member of the tetraspanin superfamily, is widely expressed on human hematopoietic and other cells [ 2 ] . It associates on B cells with a signaling complex that includes CD19 and CD21 [ 3 ] , as well as associating with MHC class II molecules [ 4 ] and other tetraspanins [ 5 6 ] . On T cells, CD81 interacts with CD4, CD8, CD82, and selected integrins [ 7 8 9 10 ] .