Words similar to tetraspanin
Example sentences for: tetraspanin
How can you use “tetraspanin” in a sentence? Here are some example sentences to help you improve your vocabulary:
We utilized a monoclonal antibody screening method involving co-immunoprecipitation of integrins under non-stringent detergent conditions [ 30 31 ] . Using this approach, we have previously discovered specific associations between particular β1 integrins and other cell surface molecules including CD147/EMMPRIN [ 31 ] , and various tetraspanin (transmembrane-4 superfamily) proteins [ 30 32 33 ] . In this report we demonstrate for the first time that CD98 constitutively and specifically associates with intact β1 integrin heterodimers.
Previously we have described the interaction of the extracellular domain of proHB-EGF with the second extracellular domain of the tetraspanin protein, monkey CD9 [ 9 ] . Tissue culture experiments using DT-sensitive transfected mouse fibroblast cell lines expressing on the cell surface both the monkey DT receptor and chimeric mouse-monkey CD9 antigen showed that the second extracellular domain of monkey CD9 antigen is able to act as a coreceptor for DT and is also responsible for the increased DT-sensitivity and affinity for DT in these cell lines [ 9 ] . These observations suggested that the CD9 antigen and proHB-EGF likely interact physically on the cell surface.
There may, for example, be a homologous tetraspanin protein that compensates for the absence of sarcospan in mice, but not in humans.
Sarcospan is homologous to the tetraspanin superfamily, members of which have been shown to facilitate both integral-membrane and membrane-proximal protein interactions involved in many different cellular processes [ 12].
Previously we have examined the protein-protein interactions of proHB-EGF with the cell-surface CD9 antigen [ 9 ] . The CD9 antigen is found on a wide variety of tissue and cell types and has been reported to be involved in such cellular processes as B-cell development, cell metastasis, platelet activation and adhesion, and cell motility [ 14 15 ] . CD9 antigen is a member of the tetraspanin superfamily and consists of two extracellular domains sandwiched between four highly-conserved hydrophobic transmembrane domains [ 14 15 ] . The second extracellular domain (75-130 amino acids) is larger than the first extracellular domain (20-27 amino acids).
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