Words similar to tetraspanin
Example sentences for: tetraspanin
How can you use “tetraspanin” in a sentence? Here are some example sentences to help you improve your vocabulary:
Previously we have examined the protein-protein interactions of proHB-EGF with the cell-surface CD9 antigen [ 9 ] . The CD9 antigen is found on a wide variety of tissue and cell types and has been reported to be involved in such cellular processes as B-cell development, cell metastasis, platelet activation and adhesion, and cell motility [ 14 15 ] . CD9 antigen is a member of the tetraspanin superfamily and consists of two extracellular domains sandwiched between four highly-conserved hydrophobic transmembrane domains [ 14 15 ] . The second extracellular domain (75-130 amino acids) is larger than the first extracellular domain (20-27 amino acids).
Sarcospan is homologous to the tetraspanin superfamily, members of which have been shown to facilitate both integral-membrane and membrane-proximal protein interactions involved in many different cellular processes [ 12].
This may hold especially true, as sarcospan appears to be member of the tetraspanin family of proteins, which have been described as molecular facilitators; alterations of such a protein's sequence could affect the proteins with which it interacts.
Previously we have described the interaction of the extracellular domain of proHB-EGF with the second extracellular domain of the tetraspanin protein, monkey CD9 [ 9 ] . Tissue culture experiments using DT-sensitive transfected mouse fibroblast cell lines expressing on the cell surface both the monkey DT receptor and chimeric mouse-monkey CD9 antigen showed that the second extracellular domain of monkey CD9 antigen is able to act as a coreceptor for DT and is also responsible for the increased DT-sensitivity and affinity for DT in these cell lines [ 9 ] . These observations suggested that the CD9 antigen and proHB-EGF likely interact physically on the cell surface.
There may, for example, be a homologous tetraspanin protein that compensates for the absence of sarcospan in mice, but not in humans.
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