Words similar to tetraspanin
Example sentences for: tetraspanin
How can you use “tetraspanin” in a sentence? Here are some example sentences to help you improve your vocabulary:
We utilized a monoclonal antibody screening method involving co-immunoprecipitation of integrins under non-stringent detergent conditions [ 30 31 ] . Using this approach, we have previously discovered specific associations between particular β1 integrins and other cell surface molecules including CD147/EMMPRIN [ 31 ] , and various tetraspanin (transmembrane-4 superfamily) proteins [ 30 32 33 ] . In this report we demonstrate for the first time that CD98 constitutively and specifically associates with intact β1 integrin heterodimers.
Previously we have examined the protein-protein interactions of proHB-EGF with the cell-surface CD9 antigen [ 9 ] . The CD9 antigen is found on a wide variety of tissue and cell types and has been reported to be involved in such cellular processes as B-cell development, cell metastasis, platelet activation and adhesion, and cell motility [ 14 15 ] . CD9 antigen is a member of the tetraspanin superfamily and consists of two extracellular domains sandwiched between four highly-conserved hydrophobic transmembrane domains [ 14 15 ] . The second extracellular domain (75-130 amino acids) is larger than the first extracellular domain (20-27 amino acids).
Sarcospan is homologous to the tetraspanin superfamily, members of which have been shown to facilitate both integral-membrane and membrane-proximal protein interactions involved in many different cellular processes [ 12].
There may, for example, be a homologous tetraspanin protein that compensates for the absence of sarcospan in mice, but not in humans.
This may hold especially true, as sarcospan appears to be member of the tetraspanin family of proteins, which have been described as molecular facilitators; alterations of such a protein's sequence could affect the proteins with which it interacts.
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