Words similar to tetrapyrroles
Example sentences for: tetrapyrroles
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Cytotoxicity of active tetrapyrroles
A variety of environmental small molecules, namely, nutrients, xenobiotics and first messengers are recognized by cells, with the help of specialized protein sensors on their surfaces [ 1 2 ] . Additionally cells also use protein-bound small molecules, such as FAD, cinnamic acid, tetrapyrroles and heme as sensors of photons and the ambient redox states [ 3 4 ] . Within cells, small molecules, such as cyclic nucleotides, are used as intracellular messengers to transduce signals arising from a variety of stimuli [ 1 2 ] . Over the past few years a combination of protein sequence analysis and biochemical studies have revealed several unifying principles that govern the recognition of small molecules by cells [ 4 5 6 7 8 9 ] . A significant component of small molecule-protein interactions is mediated via a relatively small set of ancient conserved protein domains that bind their ligands using specialized pockets [ 4 10 ] . Certain protein folds have given rise to several large superfamilies of ligand-binding domains.
Only diamagnetic tetrapyrroles are able to inhibit viruses via photoinactivation; the excited states of the paramagnetic derivatives have short half-lives and do not give significant amounts of free radicals or singlet oxygen.
Cell proliferation was measured by [ 3H]-thymidine uptake [ 8 ] . HeLa S3 cells (3 × 10 4cells/well) were incubated in 96-well plates in the presence of varying concentrations of the tetrapyrroles for 2 days at 37°C, after which 3H-TdR (1 μCi/well) was added.
The ability of a number of tetrapyrroles to inhibit virus replication was determined in CV-1 cells infected with the WR strain in the absence of compounds.
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