Words similar to tetraploid

Example sentences for: tetraploid

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When cells in M phase are used as donors, reconstructed embryos with a polar body are diploid but embryos without a polar body are tetraploid [ 14].
The availability of F3 Hprt negative ES cells allows transgenic embryos to be derived directly from transgenic ES cells by aggregating the cells with tetraploid embryos and allowing them to develop in utero.
These data demonstrate that the hprt gene is not essential for the generation of embryos from ES cells by tetraploid aggregation and that F3 cells should could provide a suitable vehicle for the direct generation of transgenic mouse embryos.
Tetraploid aggregation and β-galactosidase staining
Nagy et al demonstrated that embryos and mice could be derived solely from R1 ES cells by aggregating them with tetraploid embryos [ 7 8 ] . Although we were able to repeat these data using R1 ES cells we were unable to generate midgestation embryos from E14TG2a-derived strains of hprt negative ES cell lines using the same approach [ 9 10 11 ] . We believed it was unlikely that Hprt itself was required to generate ES cell-derived embryos because hprt knockout mice are viable and fertile [ 12 ] . E14TG2a-derived ES cell lines contain a large spontaneous deletion encompassing 55 kb of the hprt locus [ 13 ] . Therefore, it seemed possible that sequences within this region were necessary to maintain ES cell pluripotency.