Words similar to tetratricopeptide
Example sentences for: tetratricopeptide
How can you use “tetratricopeptide” in a sentence? Here are some example sentences to help you improve your vocabulary:
Mammalian protein phosphatase 5 (PP5) and its homolog protein phosphatase T1 (Ppt1p) from the yeast Saccharomyces cerevisiae contain a catalytic domain structurally related to the catalytic subunits of PP1, PP2A and PP2B, and an N-terminal domain consisting of multiple tetratricopeptide repeats (TPRs) not found in other members of this family of phosphatases [ 1 2 3 ] . Homologs have also been identified in Xenopus laevis [ 4 ] , Neurospora crassa [ 5 ] , Drosophila melanogaster [ 6 ] , Trypanosoma brucei [ 7 ] , Plasmodium falciparum [ 8 9 ] , and cauliflower [ 10 ] , and homologs for Caenorhabditis elegans, Schizosaccharomyces pombe and Arabidopsis thaliana are predicted (accession number CAB60937, CAA17690 and AAD21727, respectively).
Protein phosphatase 5 (PP5), a newer member of the PPP family, differs from the other Ser/Thr phosphatases in that it contains regulatory and (sub)cellular targeting functions within a single polypeptide [ 5 6 7 ] . While its catalytic core exhibits strong similarity to those of the other members of this family, its N-terminus consists of three tetratricopeptide repeats (TPRs) that are unique to the PP5 class.
In the past few years, a number of phosphatase activities and putative sequences have been reported in P. falciparum [ 9 ] . These include a PP2A [ 10 ] , a PP2B-like activity [ 10 ] , a unique chimeric PP2C [ 11 ] , two putative sexual-stage phosphatases - PPα [ 12 ] and PPβ [ 13 ] , and a tetratricopeptide repeat-containing phosphatase, PP5 [ 14 ] . Preliminary studies revealed the presence of a protein phosphatase activity in crude extracts of RBC-grown P. falciparum that exhibited toxin-sensitivity resembling that of PP1 [ 15 ] . Uninfected RBC, in contrast, possessed mainly a PP2A-like activity.
We provide biochemical and molecular evidence for a PP5 protein Ser/Thr phosphatase of P. falciparum that has the catalytic core of the PPP superfamily and four tetratricopeptide (34-residue) repeat (TPR) domains (Fig.
PP, protein phosphatase; MBP, myelin basic protein; TPR, tetratricopeptide repeat; AA, arachidonic acid; HA, hemagglutinin.
Loading...