Words similar to telomeres
Example sentences for: telomeres
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The genetic map shows a higher recombination rate per unit physical distance (that is, higher slope) at the telomeres, and a low male recombination rate (and thus sex-averaged rate) near the centromere (approximately 130 Mb).
A short 15 bp cis -acting sequence, cbs, is necessary and sufficient to direct breakage at or near it in Tetrahymena , presumably being the binding site of the breakage enzyme - the "cutter" [ 34 35 36 ] . The cbs sits in eliminated sequence, a short, variable distance from the positions that receive telomeres.
First, Rad26 and Rad3 are required to maintain proper telomere structure and telomere-associated gene silencing [ 43 ] . Second, chromatin-immunoprecipitation (ChIP) experiments demonstrate that over-expressed Rad3-HA exists at telomeres [ 44 ] . Third, Triton X-100 extraction, shown previously to remove non-chromatin bound proteins [ 42 ] , failed to disrupt the Rad26-GFP dots in the nuclei of cycling cells (see Figure 1).
LM-PCR directed at MAC telomeres
The in vitro properties of telomerase are consistent with its known role in creation of MAC telomeres in Tetrahymena [ 41 ] , as well as, presumably, in all other ciliates [ 9 ] . Telomerases from exconjugants of Tetrahymena and Euplotes have been extensively studied in vitro . The E. crassus enzyme can only act on oligomers that pair with telomerase template RNA at their 3' terminus, unless assisted by a dissociable factor (chromosome healing factor), which contributes extra mass to the enzyme in exconjugants [ 42 ] . Telomerase, assisted by this factor, still requires a block of dGs or telomere repeats internal to the 3' primer end [ 43 ] . In contrast, the Tetrahymena exconjugant enzyme can add to a primer completely devoid of telomere repeats in special reaction conditions, and shows no evidence of increased mass beyond that of the vegetative enzyme [ 44 ] .
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