Words similar to telomeres
Example sentences for: telomeres
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BLM has been localized to two GC-rich repeated regions (nucleolus and telomeres) [ 20] where the replication machinery is likely to need assistance to back up in order to untangle stalled forks and resolve inappropriate invasive events between repeated sequence elements found on multiple chromosomes.
Early observations by Rabl (cited by [ 3]) in plants suggested a preferential polarization of chromosomes, with their centromeres clustered at one end of the nuclear envelope (the apical side) and the telomeres at the opposite end (the basal side).
We identified 0.9 Mb of repeated sequence (less than 1% of the euchromatic genome), 40% mapping to chromosome X, 40% to chromosome 2, 15% to chromosome 3 and 3% to chromosome 4. Although there are more repeats on chromosomes X and 2, they appear to be randomly distributed and are not clustered at the centromeres or telomeres.
The in vitro properties of telomerase are consistent with its known role in creation of MAC telomeres in Tetrahymena [ 41 ] , as well as, presumably, in all other ciliates [ 9 ] . Telomerases from exconjugants of Tetrahymena and Euplotes have been extensively studied in vitro . The E. crassus enzyme can only act on oligomers that pair with telomerase template RNA at their 3' terminus, unless assisted by a dissociable factor (chromosome healing factor), which contributes extra mass to the enzyme in exconjugants [ 42 ] . Telomerase, assisted by this factor, still requires a block of dGs or telomere repeats internal to the 3' primer end [ 43 ] . In contrast, the Tetrahymena exconjugant enzyme can add to a primer completely devoid of telomere repeats in special reaction conditions, and shows no evidence of increased mass beyond that of the vegetative enzyme [ 44 ] .
First, Rad26 and Rad3 are required to maintain proper telomere structure and telomere-associated gene silencing [ 43 ] . Second, chromatin-immunoprecipitation (ChIP) experiments demonstrate that over-expressed Rad3-HA exists at telomeres [ 44 ] . Third, Triton X-100 extraction, shown previously to remove non-chromatin bound proteins [ 42 ] , failed to disrupt the Rad26-GFP dots in the nuclei of cycling cells (see Figure 1).
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