Words similar to telomerase
Example sentences for: telomerase
How can you use “telomerase” in a sentence? Here are some example sentences to help you improve your vocabulary:
Tetrahymena telomerase and the binder/cutter appear to act concertedly in vivo , as if in a physical complex [ 48 49 ] . However, this contrasts with in vitro properties of the enzyme from exconjugants: 1.) it acts on non-telomeric primers [ 44 50 ] , and 2.) it apparently is no larger than the vegetative enzyme [ 44 ] . Furthermore, telomerase can act in the vegetative MAC of Paramecium , uncoupled from chromatid breakage [ 51 ] . It remains to be seen if a complex between telomerase and binder/cutter activity does exist.
The in vitro properties of telomerase are consistent with its known role in creation of MAC telomeres in Tetrahymena [ 41 ] , as well as, presumably, in all other ciliates [ 9 ] . Telomerases from exconjugants of Tetrahymena and Euplotes have been extensively studied in vitro . The E. crassus enzyme can only act on oligomers that pair with telomerase template RNA at their 3' terminus, unless assisted by a dissociable factor (chromosome healing factor), which contributes extra mass to the enzyme in exconjugants [ 42 ] . Telomerase, assisted by this factor, still requires a block of dGs or telomere repeats internal to the 3' primer end [ 43 ] . In contrast, the Tetrahymena exconjugant enzyme can add to a primer completely devoid of telomere repeats in special reaction conditions, and shows no evidence of increased mass beyond that of the vegetative enzyme [ 44 ] .
We predict that a loose complex will be found in ciliates between telomerase and a cbs-directed binder-cutter activity.
When telomerase eventually acts, it usually encounters the eroder paused at a pause site and adds telomeric repeats to those resected chromatid ends, thus generating the reproducible spectrum of TASs observed.
It is possible that the nuclease activity of telomerase causes the erosion.