Words similar to telomerase
Example sentences for: telomerase
How can you use “telomerase” in a sentence? Here are some example sentences to help you improve your vocabulary:
In any case, telomerase in vitro requires that the 3' primer end protrudes on a single-strand tail (review: [ 9 ] ). Thus another activity is required to resect the 5' underhanging strand (see [ 67 ] ), and this enzyme too would need access to the break.
Although chromatid breakage requires an endonuclease activity, the cutter, directed by a Cbs-binding activity, no Cbs-dependent "binder/cutter" activity has been detected in vitro . The cutter could be an activity of telomerase itself [ 39 43 ] . Telomerase of both Tetrahymena and Euplotes has a single-strand endonuclease activity [ 45 43 ] . It can trim potential primers back, so that the 3' terminus pairs with template RNA [ 46 ] . Thus, while it may serve a 3' editing function, the existence of a nuclease activity in potential proximity to the site of chromatid breakage is provocative, suggesting that telomerase provides the
Tetrahymena telomerase and the binder/cutter appear to act concertedly in vivo , as if in a physical complex [ 48 49 ] . However, this contrasts with in vitro properties of the enzyme from exconjugants: 1.) it acts on non-telomeric primers [ 44 50 ] , and 2.) it apparently is no larger than the vegetative enzyme [ 44 ] . Furthermore, telomerase can act in the vegetative MAC of Paramecium , uncoupled from chromatid breakage [ 51 ] . It remains to be seen if a complex between telomerase and binder/cutter activity does exist.
Also arguing against both activities being in one inseparable entity is the apparent erosion interposed between cutting and telomerase action.
In this case all the components function with full efficiency: first, a complex of telomerase and binder/cutter bind to the binding site, then cutting of the cut-site ensues with immediate, coupled telomerase capping of the MAC-destined end, with no interposed erosion.
Loading...