Words similar to telomerase
Example sentences for: telomerase
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These include the group I [ 30 31 32 33 ] and II [ 34 35 ] introns, RNase P [ 36 37 38 ] , telomerase RNA [ 39 40 ] , tmRNA [ 41 ] , U RNA [ 42 ] , and the SRP RNA [ 43 ] . The comparative sequence analysis paradigm has been successful in determining structure over this wide range of RNA molecules.
Telomeres are not encoded in situ at the ends of MAC-destined blocks [ 32 33 ] , but are polymerized onto new ends de novo by telomerase.
The in vitro properties of telomerase are consistent with its known role in creation of MAC telomeres in Tetrahymena [ 41 ] , as well as, presumably, in all other ciliates [ 9 ] . Telomerases from exconjugants of Tetrahymena and Euplotes have been extensively studied in vitro . The E. crassus enzyme can only act on oligomers that pair with telomerase template RNA at their 3' terminus, unless assisted by a dissociable factor (chromosome healing factor), which contributes extra mass to the enzyme in exconjugants [ 42 ] . Telomerase, assisted by this factor, still requires a block of dGs or telomere repeats internal to the 3' primer end [ 43 ] . In contrast, the Tetrahymena exconjugant enzyme can add to a primer completely devoid of telomere repeats in special reaction conditions, and shows no evidence of increased mass beyond that of the vegetative enzyme [ 44 ] .
Cis -acting sequences must dictate these two contrasting behaviors of the chromatid-breakage and telomerase activities.
In any case, telomerase in vitro requires that the 3' primer end protrudes on a single-strand tail (review: [ 9 ] ). Thus another activity is required to resect the 5' underhanging strand (see [ 67 ] ), and this enzyme too would need access to the break.
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