Words similar to telomerase
Example sentences for: telomerase
How can you use “telomerase” in a sentence? Here are some example sentences to help you improve your vocabulary:
The in vitro properties of telomerase are consistent with its known role in creation of MAC telomeres in Tetrahymena [ 41 ] , as well as, presumably, in all other ciliates [ 9 ] . Telomerases from exconjugants of Tetrahymena and Euplotes have been extensively studied in vitro . The E. crassus enzyme can only act on oligomers that pair with telomerase template RNA at their 3' terminus, unless assisted by a dissociable factor (chromosome healing factor), which contributes extra mass to the enzyme in exconjugants [ 42 ] . Telomerase, assisted by this factor, still requires a block of dGs or telomere repeats internal to the 3' primer end [ 43 ] . In contrast, the Tetrahymena exconjugant enzyme can add to a primer completely devoid of telomere repeats in special reaction conditions, and shows no evidence of increased mass beyond that of the vegetative enzyme [ 44 ] .
A central and potentially contentious assumption in these two weak-sites models is that telomerase is capable of acting independently of the binder/cutter, that is, outside the widely inferred complex.
Among extant biological entities, these polymerases are encoded largely by RNA viruses and retroid viruses, but a reverse transcriptase had been recruited by eukaryotes as the catalytic subunit of the telomerase [ 98 99 ] . There seems to be a distinct possibility that both classes of RDRPs are vestiges of the ancient RNA world that have been largely displaced from cellular biochemical machinery at an early stage of evolution, because of the deleterious effects of RNA replication in DNA-based organisms, while surviving in selfish genetic elements.
We predict that a loose complex will be found in ciliates between telomerase and a cbs-directed binder-cutter activity.
Meanwhile the "impatient" telomerase dissociates from the complex, and while it is away from the site, the cutter finally cuts, and the raw end is not capped and is exposed to the exonuclease, which progresses in fits and starts, stalling at each TAS.
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