Words similar to telomerase
Example sentences for: telomerase
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A central and potentially contentious assumption in these two weak-sites models is that telomerase is capable of acting independently of the binder/cutter, that is, outside the widely inferred complex.
Tetrahymena telomerase and the binder/cutter appear to act concertedly in vivo , as if in a physical complex [ 48 49 ] . However, this contrasts with in vitro properties of the enzyme from exconjugants: 1.) it acts on non-telomeric primers [ 44 50 ] , and 2.) it apparently is no larger than the vegetative enzyme [ 44 ] . Furthermore, telomerase can act in the vegetative MAC of Paramecium , uncoupled from chromatid breakage [ 51 ] . It remains to be seen if a complex between telomerase and binder/cutter activity does exist.
Meanwhile the "impatient" telomerase dissociates from the complex, and while it is away from the site, the cutter finally cuts, and the raw end is not capped and is exposed to the exonuclease, which progresses in fits and starts, stalling at each TAS.
In any case, telomerase in vitro requires that the 3' primer end protrudes on a single-strand tail (review: [ 9 ] ). Thus another activity is required to resect the 5' underhanging strand (see [ 67 ] ), and this enzyme too would need access to the break.
Among extant biological entities, these polymerases are encoded largely by RNA viruses and retroid viruses, but a reverse transcriptase had been recruited by eukaryotes as the catalytic subunit of the telomerase [ 98 99 ] . There seems to be a distinct possibility that both classes of RDRPs are vestiges of the ancient RNA world that have been largely displaced from cellular biochemical machinery at an early stage of evolution, because of the deleterious effects of RNA replication in DNA-based organisms, while surviving in selfish genetic elements.
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