Words similar to stimulating
Example sentences for: stimulating
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4-aminopyridine, at millimolar concentrations, completely inhibits K +currents conducted by heterologously expressed KCNA channels and native GC I Kur , but lacks significant effects on native GC I Ks [ 4 12 13 20 ] . Kusaka showed that antagonism of 4-AP sensitive slowly inactivating delayed rectifier K +currents suppressed both basal and luteinizing hormone (LH)-stimulated progesterone production [ 21 ] . In this report, we extend those findings by demonstrating 4-AP inhibition of follicle stimulating hormone (FSH)-stimulated progesterone production, and by elucidating the underlying mechanisms.
In this regard, recent studies have shown that inflammatory mediators such as lipopolysaccharide (LPS), granulocyte macrophage-colony stimulating factor and leukotriene B 4 delay apoptosis and prolong neutrophil survival in culture [ 3 4 ] . Neutrophils migrating into rodent lungs in response to LPS challenge have also been reported to exhibit delayed rates of apoptosis [ 5 6 ] . Similarly, increases in cytokine and growth factor activity, and reduced neutrophil apoptosis, have been described in various inflammatory lung diseases in humans including chronic obstructive pulmonary disease, acute respiratory distress syndrome and pneumonia [ 3 7 8 ] .
Members of the Ets family of transcription factors share a unique DNA binding domain, the Ets domain, and have been shown to activate a large number of genes [ 42 43 ] and to be involved in a number of physiological and pathophysiological processes [ 44 ] . There has been accumulating evidence that Ets proteins play an important part for the invasive program of cells, particularly by stimulating the expression of protease genes [ 45 46 ] . Ets1 and Ets2 are overexpressed in a variety of tumors, including breast carcinomas ( [ 44 ] and references therein).
Although VEGF is produced locally in both of these circumstances, it is not known whether systemic administration of the factor could exacerbate these conditions by further stimulating vessel growth.
It's intellectually stimulating, " he says.
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