Words similar to srp
Example sentences for: srp
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Nop1 localization was also perturbed in tab1-1 and srp1-31, but was normal in tab3, TAB5, TAB6, and TAB7 cells (Table 2; [ 18 ] ), suggesting that a gross change in nucleolar structure is not required for bypass.
Third, both mtr10 tab 1-1and srp1-31 affect nuclear transport, suggesting that nuclear transport regulates mitotic exit.
In addition, we serendipitously found that srp1-31 but not srp1-49 could bypass cdc15Δ (Table 2; data not shown).
Both MTR10 (TAB1 ) and SRP1 belong to the nuclear transport receptor/adaptor family (reviewed by [ 38 ] ). Mutant srp1-31 and mtr10 tab 1-1cells accumulate the ribosomal protein Rpb11b in the nucleus [ 39 ] . Thus, to evaluate a potential link between nuclear transport and the tab phenotype, we evaluated the localization of Rpl11b-GFP [ 39 ] in all tab mutants.
Whereas Rpl11b-GFP was distributed relatively evenly in wild-type cells, it accumulated in the nucleus in a significant fraction of srp1-31 and net1 tab 2-1cells at 25°C and after 25°C ->37°C -> 25°C shift (Figure 6; [ 39 ] ). In addition, although mtr10 tab 1-1cells were relatively normal at 25°C, 30% of them accumulated nuclear Rpl11b after 25°C ->37°C -> 25°C shift (Figure 6).