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Example sentences for: srp
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Mtr10 assembles with and functions as a nuclear import receptor for the mRNA-binding protein Npl3 [ 36 37 ] . Interestingly, srp1-31 also inhibits nuclear import of multiple proteins including Npl3 [ 51 52 ] . Remarkably, reduction-of-function alleles of the karyopherin KAP104 were also recovered in a screen for mutations that suppressed cdc15-2 ts (A.
Both MTR10 (TAB1 ) and SRP1 belong to the nuclear transport receptor/adaptor family (reviewed by [ 38 ] ). Mutant srp1-31 and mtr10 tab 1-1cells accumulate the ribosomal protein Rpb11b in the nucleus [ 39 ] . Thus, to evaluate a potential link between nuclear transport and the tab phenotype, we evaluated the localization of Rpl11b-GFP [ 39 ] in all tab mutants.
Nop1 localization was also perturbed in tab1-1 and srp1-31, but was normal in tab3, TAB5, TAB6, and TAB7 cells (Table 2; [ 18 ] ), suggesting that a gross change in nucleolar structure is not required for bypass.
Whereas Rpl11b-GFP was distributed relatively evenly in wild-type cells, it accumulated in the nucleus in a significant fraction of srp1-31 and net1 tab 2-1cells at 25°C and after 25°C ->37°C -> 25°C shift (Figure 6; [ 39 ] ). In addition, although mtr10 tab 1-1cells were relatively normal at 25°C, 30% of them accumulated nuclear Rpl11b after 25°C ->37°C -> 25°C shift (Figure 6).
The only phenotype known to be shared by srp1, mtr10, and kap104 mutants is accumulation of the 60S ribosomal protein Rpl11b in the nucleus [ 39 ] . SRP1, MTR10, and KAP104 may also collaborate to maintain the proper nucleocytoplasmic partitioning of α factor (or factors) that regulates mitotic exit.
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