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Example sentences for: srp

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Both MTR10 (TAB1 ) and SRP1 belong to the nuclear transport receptor/adaptor family (reviewed by [ 38 ] ). Mutant srp1-31 and mtr10 tab 1-1cells accumulate the ribosomal protein Rpb11b in the nucleus [ 39 ] . Thus, to evaluate a potential link between nuclear transport and the tab phenotype, we evaluated the localization of Rpl11b-GFP [ 39 ] in all tab mutants.
These include the group I [ 30 31 32 33 ] and II [ 34 35 ] introns, RNase P [ 36 37 38 ] , telomerase RNA [ 39 40 ] , tmRNA [ 41 ] , U RNA [ 42 ] , and the SRP RNA [ 43 ] . The comparative sequence analysis paradigm has been successful in determining structure over this wide range of RNA molecules.
The only phenotype known to be shared by srp1, mtr10, and kap104 mutants is accumulation of the 60S ribosomal protein Rpl11b in the nucleus [ 39 ] . SRP1, MTR10, and KAP104 may also collaborate to maintain the proper nucleocytoplasmic partitioning of α factor (or factors) that regulates mitotic exit.
Whereas Rpl11b-GFP was distributed relatively evenly in wild-type cells, it accumulated in the nucleus in a significant fraction of srp1-31 and net1 tab 2-1cells at 25°C and after 25°C ->37°C -> 25°C shift (Figure 6; [ 39 ] ). In addition, although mtr10 tab 1-1cells were relatively normal at 25°C, 30% of them accumulated nuclear Rpl11b after 25°C ->37°C -> 25°C shift (Figure 6).