Example sentences for: srf

How can you use “srf” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The N-terminal A-box (amino acids (aa) 1-90 of Elk-1) is necessary to bind DNA, while the central B-box (aa 148-168) is the SRF interaction domain.

  • 1, when a GAL4-SRF fusion construct is transfected with the reporter, there is no increase in CAT activity.

  • SRF and TCF have been shown to form a ternary complex at the SRE in vitro . We as yet have not been able to observe a ternary complex between SRF and p35-C/EBPβ at the SRE in vitro . The mechanisms of SRE transactivation described above may help to explain the in vitro results.

  • It is possible that p35-C/EBPβ and SRF are not sufficient to form a ternary complex with the SRE in vitro , but Elk-1 may also be necessary.

  • Due to the common observations that both Elk-1 and p35-C/EBPβ transactivate the SRE, interact with SRF, and are responsive to Ras-dependent signaling pathways, we hypothesized that Elk-1 and p35-C/EBPβ may both be necessary for maximal induction of SRF dependent transcription.


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