Example sentences for: srf

How can you use “srf” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Interestingly, when all three constructs - SRF, Elk-1, and p35-C/EBPβ-are cotransfected with the reporter construct, there is an average 260-fold increase in CAT activity in the presence of activated Ras.

  • SRF and TCF have been shown to form a ternary complex at the SRE in vitro . We as yet have not been able to observe a ternary complex between SRF and p35-C/EBPβ at the SRE in vitro . The mechanisms of SRE transactivation described above may help to explain the in vitro results.

  • Therefore, C/EBPβ is a target of a Ras-dependent signaling pathway that regulates its interaction with SRF.

  • We have also shown that both p35-C/EBPβ and p20-C/EBPβ could interact with SRF in vivo and that the interaction between SRF and p35-C/EBPβ, but not between SRF and p20-C/EBPβ, is stimulated by activated Ras.

  • Since Elk-1 and p35-C/EBPβ synergize in transactivation of SRF-dependent transcription using a GAL4-dependent promoter, we next tested if Elk-1 and p35-C/EBPβ could also synergize in transactivation of a native SRF binding site, namely the c-fos SRE.


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