Example sentences for: srf

How can you use “srf” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In this study, we show that p35-C/EBPβ and the TCF family member Elk-1 synergize in transactivation of SRF dependent transcription of both a Gal4 dependent reporter and an SRE-driven reporter construct, but only in response to mitogenic stimulation by Ras.

  • These results suggest a new mechanism for transactivation of the SRE, where a competent transcriptional complex consisting of at least SRF, TCF, and p35-C/EBPβ participate in transactivation in response to Ras.

  • We have shown that C/EBPβ interacts with the A-box of Elk-1, while SRF has previously been shown to interact with the B-box [ 16].

  • Therefore, C/EBPβ and SRF interact with two distinct domains of Elk-1, as well as with each other, which could allow formation of a complex of the three transcription factors.

  • The N-terminal A-box (amino acids (aa) 1-90 of Elk-1) is necessary to bind DNA, while the central B-box (aa 148-168) is the SRF interaction domain.


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