Example sentences for: srebp-

How can you use “srebp-” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Within the SREBP promoter element, the liver X receptor (LXR)-responsive elements (LXRE) may have an important role [ 34 ] . LC-PUFA may affect SREBP-1c mediated transcription via several mechanisms.

  • Thus, LC-PUFA could have induced a joint SREBP-1c/NFY effect on common promoter elements.

  • In the liver, intestine, adipose, and mammary gland, the cytoplasmic form synthesizes acetyl CoA for lipogenesis [ 46 ] . It is regulated by SREBP-1a, -1c- and -2, as well as SP1 and SP3 binding to GC-boxes; the promoter also contains an E-box [ 47 ] . It is down regulated with fasting, and induced with re-feeding; such dietary regulation does not exist in SREBP-1 knockout mice [ 48 ] . More generally, acyl CoA synthase is reported to be PPARα-activated [ 49 ] . The observed down regulation is consistent with less acetyl CoA available for the ACC reaction, as well as a plethora of other reactions.

  • SREBP-1c, in addition to interacting with SREs, binds E-box containing promoters [ 38 ] . E-box containing promoters were not examined so the current data analysis could have underestimated SREBP-1-linked effects.

  • The probe set in the Affymetrix Murine 11 k chip could not differentiate between the -1a and -1c splicing variants of SREBP-1.


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