Words similar to srebp-
Example sentences for: srebp-
How can you use “srebp-” in a sentence? Here are some example sentences to help you improve your vocabulary:
Numerous hepatic genes containing SRE promoters were regulated by LC-PUFA in the present experiments, including SREBP-1 itself (consistent with [ 35 36 ] ). Also regulated were genes involved in triacylglycerol synthesis (Gpam), FA synthesis and elongation (Acas1, Acly, FA synthase, Spot14, Elovl2; Elovl2 may speculatively contain an SRE as described by Moon and colleagues [ 35 ] ), FA desaturation (Scd1), gluconeogenesis (Pck1), cytochrome p450 metabolism (Cyp4a-10 and -14), FA transport (Cd36), cholesterol metabolism and transport (Fpps), and ketone body formation (mitochondrial Hmgcs2).
Chronic feeding of fish and AA-enriched fungal oils broadly affected genes regulated by PPARα, HNFα, and SREBP-1 in the liver; transcription factors implicated in lipid metabolism as well as other processes.
Overall, LC-PUFA may up regulate Pck1, the rate-limiting enzyme in gluconeogenesis, via cAMP-, SREBP-1- and/or PPAR-signaling [ 57 ] . This has the overall effect of limiting fat accumulation and shunting metabolic flux to gluconeogenesis.
One mechanism is to antagonize activation of the LXR receptor leading to fewer LXR/RXR heterodimer complexes to bind the LXRE in the SREBP-1c promoter and less SREBP-1c-mediated transcription of SRE-containing genes [ 34 ] . The PPARα signaling cascade intertwines with SREBP pathways since LC-PUFA also activate PPARα, which can induce LXRα expression [ 17 ] .
The probe set in the Affymetrix Murine 11 k chip could not differentiate between the -1a and -1c splicing variants of SREBP-1.
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