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Example sentences for: srl

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The expression of cyclin E and G, which controls the cell cycle progression and G0/S and G1 phase of cell cycle, was decreased with TAC and SRL therapy.
The results of cyclins G and E mRNA expressed as ratio with β-actin shown in Figure 5. A significant decrease (p < 0.01) in Cyclin G mRNA in lymphocytes from patients treated with TAC and SRL (0.
A number of studies have demonstrated that long treatment of both CsA and TAC is associated many side effects such as nephrotoxicity, hypertension, and gingival hyperplasia [ 1 2 ] . Rapamycin clinically termed, as Sirolimus (SRL) is a new immunosuppressive agent, which is structurally similar to TAC, binds to same binding protein FKBP, but has different mechanism of action [ 3 ] . Both clinical and experimental studies demonstrated that SRL when used either with CsA or alone is associated with side effects like hyperlipidemia, thrombocytopenia and nephrotoxicity [ 4 5 6 7 ] . SRL and TAC compete for the same binding site and hence it was thought they could not be used concomitantly.
The results expressed as ratio with β-actin, demonstrate a marked decrease (p < 0.05) in TNF-α levels in lymphocytes from patients treated with TAC and SRL (0.
Recently [ 11 ] , we have demonstrated the efficacy of combination of low doses of SRL with either CsA or TAC to inhibit lymphocyte proliferation.