Words similar to sry
Example sentences for: sry
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Beyond SRY , there are several autosomal genes including the SRY -related SOX9 gene [ 9, 10], MIS [ 11, 12], SF1 [ 13], WT1 [ 14] and DMRT1 [ 15] that contribute to sexual organ formation, alterations of which can cause male-to-female sex reversal in XY males.
Sry
These observations led to a search for the testis-determining factor on the Y chromosome culminating in isolation of the SRY gene [ 5], which is sex-determining in humans [ 6, 7] and mice [ 8].
Human sequences : KIAA0808 mRNA (AB018351), KIAA0808 protein (BAA34528); KIAA0737 (C14ORF92) mRNA (NM_014828), KIAA0737 predicted protein (NP_055643); C20ORF100 mRNA (NM_032883), C20ORF100 predicted protein (NP_116272); TNRC9 mRNA (XM_049037), TNRC9 predicted protein (XP_049037), SEX determining region Y protein (SRY) (XP_010468).
Long polyglutamine repeats have been found in a number of transcription factors [ 39 ] . Notably, the C-terminus of murine HMG-box protein SRY contains a large polyglutamine repeat region that is responsible for the sex-determining function of this protein [ 40 ] . However, a number of neurodegenerative disorders, such as Huntington disease and spinobulbar muscular atrophy, are also strongly associated with proteins containing a polyglutamine stretch [ 41 ] . Conformational change and protein misfolding in the expanded polyglutamine region is believed to be the molecular basis of the pathogenesis [ 42 ] . Whether the presence of polyglutamine repeats in the C-terminus of human TNRC9 is important for function or alternatively hinders its ability to form a functional protein remains to be determined.
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