Words similar to sry
Example sentences for: sry
How can you use “sry” in a sentence? Here are some example sentences to help you improve your vocabulary:
These observations led to a search for the testis-determining factor on the Y chromosome culminating in isolation of the SRY gene [ 5], which is sex-determining in humans [ 6, 7] and mice [ 8].
Long polyglutamine repeats have been found in a number of transcription factors [ 39 ] . Notably, the C-terminus of murine HMG-box protein SRY contains a large polyglutamine repeat region that is responsible for the sex-determining function of this protein [ 40 ] . However, a number of neurodegenerative disorders, such as Huntington disease and spinobulbar muscular atrophy, are also strongly associated with proteins containing a polyglutamine stretch [ 41 ] . Conformational change and protein misfolding in the expanded polyglutamine region is believed to be the molecular basis of the pathogenesis [ 42 ] . Whether the presence of polyglutamine repeats in the C-terminus of human TNRC9 is important for function or alternatively hinders its ability to form a functional protein remains to be determined.
The asparagine at position 10 makes contact with DNA in the hSRY-DNA complex [ 24 ] , as does the serine at this position in the NHP6A-DNA complex [ 7 ] . A hydrophobic residue at position 32 that can partially intercalate into DNA plays a role in DNA binding of some sequence-independent HMG-box proteins [ 7 25 26 ] . Position 32 is the hydrophobic residue phenylalanine in TOX, in contrast to the polar residues found at this position in SRY, SOX proteins and LEF-1.
This latter mechanism is thought to relate SRY to the X-linked SOX3 gene in mammals [ 23].
Because there are rodent species with no SRY gene and no Y chromosome [ 16], any of these genes or the X-linked DAX1 gene [ 17] might be considered candidates for a sex-determining gene in the XX rodents such as mole voles whose body plan is not so different from that of mice.
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